Abstract
B-cells contribute to MS pathogenesis. The association of circulating B-cell phenotypes with combined unique active lesions (CUA) on MRI at 48 weeks follow-up was investigated in 50 interferon beta-treated MS patients. Transitional B-cell proportions were lower in participants with CUA at week 0 and 48 [p = 0.004, p = 0.002]. A decrease in circulating anti-EBNA-1 IgG levels between week 0 and 48 associated with absence of CUA [p = 0.047], but not with B-cell profiles. In a multi-factor model for CUA-risk, transitional B-cell proportions contributed independent from NK/T-cell ratio, change in anti-EBNA-1 IgG, and vitamin D supplementation. Transitional B-cells may predict treatment response in MS.
Original language | English |
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Article number | 577664 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 358 |
DOIs | |
Publication status | Published - 15 Sept 2021 |
Keywords
- Multiple sclerosis
- Epstein-Barr virus
- Transitional B cells
- IFN-b
- Disease activity
- Systems biology
- EPSTEIN-BARR-VIRUS
- VITAMIN-D-3 SUPPLEMENTATION
- DISEASE-ACTIVITY
- FINGOLIMOD
- DIFFERENTIATION
- OCRELIZUMAB
- THERAPIES
- FOLLICLES
- INFECTION
- ONSET