Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients

M. Mimpen, J. Damoiseaux*, W. van Doorn, L. Rolf, A.H. Muris, R. Hupperts, M.M. van Luijn, O. Gerlach, J. Smolders

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

B-cells contribute to MS pathogenesis. The association of circulating B-cell phenotypes with combined unique active lesions (CUA) on MRI at 48 weeks follow-up was investigated in 50 interferon beta-treated MS patients. Transitional B-cell proportions were lower in participants with CUA at week 0 and 48 [p = 0.004, p = 0.002]. A decrease in circulating anti-EBNA-1 IgG levels between week 0 and 48 associated with absence of CUA [p = 0.047], but not with B-cell profiles. In a multi-factor model for CUA-risk, transitional B-cell proportions contributed independent from NK/T-cell ratio, change in anti-EBNA-1 IgG, and vitamin D supplementation. Transitional B-cells may predict treatment response in MS.
Original languageEnglish
Article number577664
Number of pages8
JournalJournal of Neuroimmunology
Volume358
DOIs
Publication statusPublished - 15 Sep 2021

Keywords

  • Multiple sclerosis
  • Epstein-Barr virus
  • Transitional B cells
  • IFN-b
  • Disease activity
  • Systems biology
  • EPSTEIN-BARR-VIRUS
  • VITAMIN-D-3 SUPPLEMENTATION
  • DISEASE-ACTIVITY
  • FINGOLIMOD
  • DIFFERENTIATION
  • OCRELIZUMAB
  • THERAPIES
  • FOLLICLES
  • INFECTION
  • ONSET

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