Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study

M.H. Dueck, F. Petzke, H.J. Gerbershagen, M. Paul, V. Hesselmann, R. Girnus, B. Krug, B. Sorger, R.W. Goebel, R. Lehrke, V. Sturm, U. Boemer

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Abstract

Background: Functional magnetic resonance imaging (fMRI) using blood-oxygen-level-dependent (BOLD) contrasts is a common method for studying sensory or cognitive brain functions. The aim of the present study was to assess the effect of the intravenous anaesthetic propofol on auditory-induced brain activation using BOLD contrast fMRI. Methods: In eight neurosurgical patients, musical stimuli were presented binaurally in a block design. Imaging was performed under five conditions: no propofol (or wakefulness) and propofol plasma target concentrations of 0.5, 1.0, 1.5, and 2.0 mu g ml(-1). Results: During wakefulness we found activations in the superior temporal gyrus (STG) corresponding to the primary and secondary auditory cortex as well as in regions of higher functions of auditory information processing. The BOLD response decreased with increasing concentrations of propofol but remained partially preserved in areas of basic auditory processing in the STG during propofol 2.0 mu g ml(-1). Conclusions: Our results suggest a dose-dependent impairment of central processing of auditory information after propofol administration. These results are consistent with electrophysiological findings measuring neuronal activity directly, thus suggesting a dose-dependent impairment of central processing of auditory information after propofol administration. However, propofol did not totally blunt primary cortical responses to acoustic stimulation, indicating that patients may process auditory information under general anaesthesia.
Original languageEnglish
Pages (from-to)784-791
JournalActa Anaesthesiologica Scandinavica
Volume49
Issue number6
DOIs
Publication statusPublished - 1 Jan 2005

Cite this

Dueck, M.H. ; Petzke, F. ; Gerbershagen, H.J. ; Paul, M. ; Hesselmann, V. ; Girnus, R. ; Krug, B. ; Sorger, B. ; Goebel, R.W. ; Lehrke, R. ; Sturm, V. ; Boemer, U. / Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study. In: Acta Anaesthesiologica Scandinavica. 2005 ; Vol. 49, No. 6. pp. 784-791.
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title = "Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study",
abstract = "Background: Functional magnetic resonance imaging (fMRI) using blood-oxygen-level-dependent (BOLD) contrasts is a common method for studying sensory or cognitive brain functions. The aim of the present study was to assess the effect of the intravenous anaesthetic propofol on auditory-induced brain activation using BOLD contrast fMRI. Methods: In eight neurosurgical patients, musical stimuli were presented binaurally in a block design. Imaging was performed under five conditions: no propofol (or wakefulness) and propofol plasma target concentrations of 0.5, 1.0, 1.5, and 2.0 mu g ml(-1). Results: During wakefulness we found activations in the superior temporal gyrus (STG) corresponding to the primary and secondary auditory cortex as well as in regions of higher functions of auditory information processing. The BOLD response decreased with increasing concentrations of propofol but remained partially preserved in areas of basic auditory processing in the STG during propofol 2.0 mu g ml(-1). Conclusions: Our results suggest a dose-dependent impairment of central processing of auditory information after propofol administration. These results are consistent with electrophysiological findings measuring neuronal activity directly, thus suggesting a dose-dependent impairment of central processing of auditory information after propofol administration. However, propofol did not totally blunt primary cortical responses to acoustic stimulation, indicating that patients may process auditory information under general anaesthesia.",
author = "M.H. Dueck and F. Petzke and H.J. Gerbershagen and M. Paul and V. Hesselmann and R. Girnus and B. Krug and B. Sorger and R.W. Goebel and R. Lehrke and V. Sturm and U. Boemer",
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Dueck, MH, Petzke, F, Gerbershagen, HJ, Paul, M, Hesselmann, V, Girnus, R, Krug, B, Sorger, B, Goebel, RW, Lehrke, R, Sturm, V & Boemer, U 2005, 'Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study', Acta Anaesthesiologica Scandinavica, vol. 49, no. 6, pp. 784-791. https://doi.org/10.1111/j.1399-6576.2005.00703.x

Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study. / Dueck, M.H.; Petzke, F.; Gerbershagen, H.J.; Paul, M.; Hesselmann, V.; Girnus, R.; Krug, B.; Sorger, B.; Goebel, R.W.; Lehrke, R.; Sturm, V.; Boemer, U.

In: Acta Anaesthesiologica Scandinavica, Vol. 49, No. 6, 01.01.2005, p. 784-791.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study

AU - Dueck, M.H.

AU - Petzke, F.

AU - Gerbershagen, H.J.

AU - Paul, M.

AU - Hesselmann, V.

AU - Girnus, R.

AU - Krug, B.

AU - Sorger, B.

AU - Goebel, R.W.

AU - Lehrke, R.

AU - Sturm, V.

AU - Boemer, U.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: Functional magnetic resonance imaging (fMRI) using blood-oxygen-level-dependent (BOLD) contrasts is a common method for studying sensory or cognitive brain functions. The aim of the present study was to assess the effect of the intravenous anaesthetic propofol on auditory-induced brain activation using BOLD contrast fMRI. Methods: In eight neurosurgical patients, musical stimuli were presented binaurally in a block design. Imaging was performed under five conditions: no propofol (or wakefulness) and propofol plasma target concentrations of 0.5, 1.0, 1.5, and 2.0 mu g ml(-1). Results: During wakefulness we found activations in the superior temporal gyrus (STG) corresponding to the primary and secondary auditory cortex as well as in regions of higher functions of auditory information processing. The BOLD response decreased with increasing concentrations of propofol but remained partially preserved in areas of basic auditory processing in the STG during propofol 2.0 mu g ml(-1). Conclusions: Our results suggest a dose-dependent impairment of central processing of auditory information after propofol administration. These results are consistent with electrophysiological findings measuring neuronal activity directly, thus suggesting a dose-dependent impairment of central processing of auditory information after propofol administration. However, propofol did not totally blunt primary cortical responses to acoustic stimulation, indicating that patients may process auditory information under general anaesthesia.

AB - Background: Functional magnetic resonance imaging (fMRI) using blood-oxygen-level-dependent (BOLD) contrasts is a common method for studying sensory or cognitive brain functions. The aim of the present study was to assess the effect of the intravenous anaesthetic propofol on auditory-induced brain activation using BOLD contrast fMRI. Methods: In eight neurosurgical patients, musical stimuli were presented binaurally in a block design. Imaging was performed under five conditions: no propofol (or wakefulness) and propofol plasma target concentrations of 0.5, 1.0, 1.5, and 2.0 mu g ml(-1). Results: During wakefulness we found activations in the superior temporal gyrus (STG) corresponding to the primary and secondary auditory cortex as well as in regions of higher functions of auditory information processing. The BOLD response decreased with increasing concentrations of propofol but remained partially preserved in areas of basic auditory processing in the STG during propofol 2.0 mu g ml(-1). Conclusions: Our results suggest a dose-dependent impairment of central processing of auditory information after propofol administration. These results are consistent with electrophysiological findings measuring neuronal activity directly, thus suggesting a dose-dependent impairment of central processing of auditory information after propofol administration. However, propofol did not totally blunt primary cortical responses to acoustic stimulation, indicating that patients may process auditory information under general anaesthesia.

U2 - 10.1111/j.1399-6576.2005.00703.x

DO - 10.1111/j.1399-6576.2005.00703.x

M3 - Article

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SP - 784

EP - 791

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

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ER -