Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

Bart A. W. Jacobs, Maarten J. Deenen, Dick Pluim, J. G. Coen van Hasselt, Martin D. Krahenbuhl, Robin M. J. M. van Geel, Niels de Vries, Hilde Rosing, Didier Meulendijks, Artur M. Burylo, Annemieke Cats, Jos H. Beijnen, Alwin D. R. Huitema, Jan H. M. Schellens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)706-716
JournalBritish Journal of Clinical Pharmacology
Issue number3
Publication statusPublished - Sep 2016


  • 5-fluorouracil
  • capecitabine
  • circadian rhythm
  • dihydropyrimidine dehydrogenase
  • thymidylate synthase

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