Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

Bart A. W. Jacobs, Maarten J. Deenen, Dick Pluim, J. G. Coen van Hasselt, Martin D. Krahenbuhl, Robin M. J. M. van Geel, Niels de Vries, Hilde Rosing, Didier Meulendijks, Artur M. Burylo, Annemieke Cats, Jos H. Beijnen, Alwin D. R. Huitema, Jan H. M. Schellens

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)706-716
JournalBritish Journal of Clinical Pharmacology
Volume82
Issue number3
DOIs
Publication statusPublished - Sep 2016

Keywords

  • 5-fluorouracil
  • capecitabine
  • circadian rhythm
  • dihydropyrimidine dehydrogenase
  • thymidylate synthase

Cite this

Jacobs, B. A. W., Deenen, M. J., Pluim, D., van Hasselt, J. G. C., Krahenbuhl, M. D., van Geel, R. M. J. M., de Vries, N., Rosing, H., Meulendijks, D., Burylo, A. M., Cats, A., Beijnen, J. H., Huitema, A. D. R., & Schellens, J. H. M. (2016). Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers. British Journal of Clinical Pharmacology, 82(3), 706-716. https://doi.org/10.1111/bcp.13007