Promising effects of adenosine triphosphate infusion on nutritional status and quality of life in advanced non-smell-cell lung cancer: a randomized clinical trial

P.C. Dagnelie, H.J. Agteresch

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Previous studies animal and phase I/II studies suggested that regular ATP infusions may inhibit loss of body weight in cancer. In this report, we summarize data from a recent trial (Agteresch et aL [2000a] J Natl Cancer Inst 92:321-328; Agteresch et al. [2000b] Eur J Clin Pbarmacol 56:49-55) in 58 patients with non-small-cell lung cancer, stage IIIB or IV. Patients were randomized to receive either 10 intravenous 30-h ATP infusions every 2 to 4 weeks (n = 28), or no ATP (n - 30). Body weight, body composition (anthropometry, isotope dilution), muscle strength (elbow flexor and knee extensor), energy intake (3-day food record), and quality of life (validated Rotterdam Symptom Checklist, RSCL) were assessed at 4-week intervals during 28 weeks. Between-group differences were tested for statistical significance (P
Original languageEnglish
Pages (from-to)146-151
Number of pages5
JournalDrug Development Research
Publication statusPublished - 1 Jan 2003

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