Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers

Jarne M. van Hattem, Maris S. Arcilla, Martin C. J. Bootsma, Perry J. van Genderen, Abraham Goorhuis, Martin P. Grobusch, Nicky Molhoek, Astrid Oude Lashof, Constance Schultsz, Ellen E. Stobberingh, Henri A. Verbrugh, Menno D. de Jong, Damian C. Melles, John Penders*

*Corresponding author for this work

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Abstract

Aim: The aim was to study acquisition and persistence of carbapenemase-producing Enterobacteriaceae (CPE) among travelers. Materials & methods: Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. Results: Five travelers, all visiting Asia outside the Indian subcontinent, acquired CPE. One traveler persistently carried the same OXA-244 CPE up to 6 months post-travel. Three months after travel, her co-traveling spouse also became positive for this OXA-244 CPE strain, suggesting clonal transmission within this household. Conclusion: Acquisition of CPE is not restricted to travelers to the Indian subcontinent and/or to travelers seeking healthcare during travel and can persist up to at least 6 months post-travel.
Original languageEnglish
Pages (from-to)857-864
Number of pages8
JournalFuture Microbiology
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Enterobacteriaceae
  • carbapenemases
  • transmission
  • travel

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