Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers

Jarne M. van Hattem; Maris S. Arcilla; Martin C. J. Bootsma; Perry J. van Genderen; Abraham Goorhuis; Martin P. Grobusch; Nicky Molhoek; Astrid Oude Lashof; Constance Schultsz; Ellen E. Stobberingh; Henri A. Verbrugh; Menno D. de Jong; Damian C. Melles; John Penders

doi:10.2217/fmb.16.18

Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers

Jarne M. van Hattem, Maris S. Arcilla, Martin C. J. Bootsma, Perry J. van Genderen, Abraham Goorhuis, Martin P. Grobusch, Nicky Molhoek, Astrid Oude Lashof, Constance Schultsz, Ellen E. Stobberingh, Henri A. Verbrugh, Menno D. de Jong, Damian C. Melles, John Penders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aim: The aim was to study acquisition and persistence of carbapenemase-producing Enterobacteriaceae (CPE) among travelers. Materials & methods: Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. Results: Five travelers, all visiting Asia outside the Indian subcontinent, acquired CPE. One traveler persistently carried the same OXA-244 CPE up to 6 months post-travel. Three months after travel, her co-traveling spouse also became positive for this OXA-244 CPE strain, suggesting clonal transmission within this household. Conclusion: Acquisition of CPE is not restricted to travelers to the Indian subcontinent and/or to travelers seeking healthcare during travel and can persist up to at least 6 months post-travel.

Original language	English
Pages (from-to)	857-864
Number of pages	8
Journal	Future Microbiology
Volume	11
Issue number	7
DOIs	https://doi.org/10.2217/fmb.16.18
Publication status	Published - Jul 2016

Keywords

Enterobacteriaceae
carbapenemases
transmission
travel

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10.2217/fmb.16.18

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Cite this

van Hattem, J. M., Arcilla, M. S., Bootsma, M. C. J., van Genderen, P. J., Goorhuis, A., Grobusch, M. P., Molhoek, N., Oude Lashof, A., Schultsz, C., Stobberingh, E. E., Verbrugh, H. A., de Jong, M. D., Melles, D. C., & Penders, J. (2016). Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers. Future Microbiology, 11(7), 857-864. https://doi.org/10.2217/fmb.16.18

@article{141049a6761f49f199378987d2585259,

title = "Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers",

abstract = "Aim: The aim was to study acquisition and persistence of carbapenemase-producing Enterobacteriaceae (CPE) among travelers. Materials & methods: Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. Results: Five travelers, all visiting Asia outside the Indian subcontinent, acquired CPE. One traveler persistently carried the same OXA-244 CPE up to 6 months post-travel. Three months after travel, her co-traveling spouse also became positive for this OXA-244 CPE strain, suggesting clonal transmission within this household. Conclusion: Acquisition of CPE is not restricted to travelers to the Indian subcontinent and/or to travelers seeking healthcare during travel and can persist up to at least 6 months post-travel.",

keywords = "Enterobacteriaceae, carbapenemases, transmission, travel",

author = "{van Hattem}, {Jarne M.} and Arcilla, {Maris S.} and Bootsma, {Martin C. J.} and {van Genderen}, {Perry J.} and Abraham Goorhuis and Grobusch, {Martin P.} and Nicky Molhoek and {Oude Lashof}, Astrid and Constance Schultsz and Stobberingh, {Ellen E.} and Verbrugh, {Henri A.} and {de Jong}, {Menno D.} and Melles, {Damian C.} and John Penders",

year = "2016",

month = jul,

doi = "10.2217/fmb.16.18",

language = "English",

volume = "11",

pages = "857--864",

journal = "Future Microbiology",

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number = "7",

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van Hattem, JM, Arcilla, MS, Bootsma, MCJ, van Genderen, PJ, Goorhuis, A, Grobusch, MP, Molhoek, N, Oude Lashof, A, Schultsz, C, Stobberingh, EE, Verbrugh, HA, de Jong, MD, Melles, DC & Penders, J 2016, 'Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers', Future Microbiology, vol. 11, no. 7, pp. 857-864. https://doi.org/10.2217/fmb.16.18

TY - JOUR

T1 - Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers

AU - van Hattem, Jarne M.

AU - Arcilla, Maris S.

AU - Bootsma, Martin C. J.

AU - van Genderen, Perry J.

AU - Goorhuis, Abraham

AU - Grobusch, Martin P.

AU - Molhoek, Nicky

AU - Oude Lashof, Astrid

AU - Schultsz, Constance

AU - Stobberingh, Ellen E.

AU - Verbrugh, Henri A.

AU - de Jong, Menno D.

AU - Melles, Damian C.

AU - Penders, John

PY - 2016/7

Y1 - 2016/7

N2 - Aim: The aim was to study acquisition and persistence of carbapenemase-producing Enterobacteriaceae (CPE) among travelers. Materials & methods: Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. Results: Five travelers, all visiting Asia outside the Indian subcontinent, acquired CPE. One traveler persistently carried the same OXA-244 CPE up to 6 months post-travel. Three months after travel, her co-traveling spouse also became positive for this OXA-244 CPE strain, suggesting clonal transmission within this household. Conclusion: Acquisition of CPE is not restricted to travelers to the Indian subcontinent and/or to travelers seeking healthcare during travel and can persist up to at least 6 months post-travel.

AB - Aim: The aim was to study acquisition and persistence of carbapenemase-producing Enterobacteriaceae (CPE) among travelers. Materials & methods: Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. Results: Five travelers, all visiting Asia outside the Indian subcontinent, acquired CPE. One traveler persistently carried the same OXA-244 CPE up to 6 months post-travel. Three months after travel, her co-traveling spouse also became positive for this OXA-244 CPE strain, suggesting clonal transmission within this household. Conclusion: Acquisition of CPE is not restricted to travelers to the Indian subcontinent and/or to travelers seeking healthcare during travel and can persist up to at least 6 months post-travel.

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KW - transmission

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