Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro

INIS

• tools 100%
• assessments 100%
• toxicity 100%
• mice 100%
• hepatocytes 100%
• in vitro 100%
• plasmids 100%
• pyrene 60%
• induction 40%
• in vivo 40%
• mutants 40%
• transferases 40%
• cyclophosphamide 40%
• bleomycin 40%
• testing 20%
• levels 20%
• validation 20%
• specificity 20%
• increasing 20%
• design 20%
• metabolism 20%
• concentration 20%
• enzymes 20%
• risk assessment 20%
• hazards 20%
• ultraviolet radiation 20%
• capacity 20%
• xenobiotics 20%
• enzyme activity 20%
• colonies 20%
• residues 20%
• serine 20%
• glutathione 20%
• cytochromes 20%

Keyphrases

• Primary Hepatocytes 100%
• Plasmid 100%
• Genotoxicity Assessment 100%
• LacZ 100%
• Benzo(a)pyrene 60%
• Genotoxicity 40%
• Etoposide 40%
• Cyclophosphamide 40%
• Bleomycin 40%
• Hepatocytes 20%
• Xenobiotic Metabolism 20%
• UDP-glucuronosyltransferase 20%
• Enzyme Activity 20%
• In Vivo Test 20%
• In Vitro Activity 20%
• Phase II Enzymes 20%
• Metabolic Flexibility 20%
• Safety Assessment 20%
• Concentration-dependent 20%
• Cytochrome P450 1A1 (CYP1A1) 20%
• Mammalian Cells 20%
• Genotoxicity Assay 20%
• Genotoxic Activity 20%
• Mutant Frequency 20%
• Ultraviolet Treatment 20%
• Rescue Assay 20%
• Genotoxic Risk 20%
• LacZ Reporter 20%
• Reporter Mice 20%
• Glutathione S-transferase Activity 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Benzo(a)pyrene 100%
• Genotoxicity 100%
• Protein P53 66%
• Etoposide 66%
• Cyclophosphamide 66%
• Bleomycin 66%
• Glutathione 33%
• Mutagen Testing 33%
• Xenobiotic Metabolism 33%
• Transferase 33%
• Serine 33%
• Cytochrome P450 1A1 33%
• Safety Assessment 33%
• Glucuronosyltransferase 33%
• Uridine Diphosphate 33%