Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel

C. Cao; Y. Temel; A. Blokland; H. Ozen; H.W.M. Steinbusch; R. Vlamings; H.P. Nguyen; S. von Horsten; C. Schmitz; V. Visser-Vandewalle

doi:10.1016/j.bbr.2006.02.028

Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel

C. Cao
, Y. Temel^*
, A. Blokland
, H. Ozen
, H.W.M. Steinbusch
, R. Vlamings
, H.P. Nguyen
, S. von Horsten
, C. Schmitz
, V. Visser-Vandewalle

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We tested the hypothesis that a recently developed transgenic rat model of Huntington's disease (tgHD rats) showed an age-and genotype-dependent change in psychomotor performance and in the frequency of choreiform movements similar to HD patients. Wild type and tgHD (homozygotic and heterozygotic) rats were behaviorally tested at an age of 15 and 20 months. Our results show that tgHD rats exhibit an age-, and genotype-dependent deterioration of the psychomotor performance and choreiform, symptoms, closely mimicking the clinical time course changes of psychomotor symptoms of HD patients. These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD.

Original language	English
Pages (from-to)	257-261
Journal	Behavioural Brain Research
Volume	170
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2006.02.028
Publication status	Published - 1 Jan 2006

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Cao, C., Temel, Y., Blokland, A., Ozen, H., Steinbusch, H. W. M., Vlamings, R., Nguyen, H. P., von Horsten, S., Schmitz, C., & Visser-Vandewalle, V. (2006). Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel. Behavioural Brain Research, 170(2), 257-261. https://doi.org/10.1016/j.bbr.2006.02.028

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title = "Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel",

abstract = "We tested the hypothesis that a recently developed transgenic rat model of Huntington's disease (tgHD rats) showed an age-and genotype-dependent change in psychomotor performance and in the frequency of choreiform movements similar to HD patients. Wild type and tgHD (homozygotic and heterozygotic) rats were behaviorally tested at an age of 15 and 20 months. Our results show that tgHD rats exhibit an age-, and genotype-dependent deterioration of the psychomotor performance and choreiform, symptoms, closely mimicking the clinical time course changes of psychomotor symptoms of HD patients. These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD. ",

author = "C. Cao and Y. Temel and A. Blokland and H. Ozen and H.W.M. Steinbusch and R. Vlamings and H.P. Nguyen and \{von Horsten\}, S. and C. Schmitz and V. Visser-Vandewalle",

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doi = "10.1016/j.bbr.2006.02.028",

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T1 - Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel

AU - Cao, C.

AU - Temel, Y.

AU - Blokland, A.

AU - Ozen, H.

AU - Steinbusch, H.W.M.

AU - Vlamings, R.

AU - Nguyen, H.P.

AU - von Horsten, S.

AU - Schmitz, C.

AU - Visser-Vandewalle, V.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - We tested the hypothesis that a recently developed transgenic rat model of Huntington's disease (tgHD rats) showed an age-and genotype-dependent change in psychomotor performance and in the frequency of choreiform movements similar to HD patients. Wild type and tgHD (homozygotic and heterozygotic) rats were behaviorally tested at an age of 15 and 20 months. Our results show that tgHD rats exhibit an age-, and genotype-dependent deterioration of the psychomotor performance and choreiform, symptoms, closely mimicking the clinical time course changes of psychomotor symptoms of HD patients. These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD.

AB - We tested the hypothesis that a recently developed transgenic rat model of Huntington's disease (tgHD rats) showed an age-and genotype-dependent change in psychomotor performance and in the frequency of choreiform movements similar to HD patients. Wild type and tgHD (homozygotic and heterozygotic) rats were behaviorally tested at an age of 15 and 20 months. Our results show that tgHD rats exhibit an age-, and genotype-dependent deterioration of the psychomotor performance and choreiform, symptoms, closely mimicking the clinical time course changes of psychomotor symptoms of HD patients. These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD.

U2 - 10.1016/j.bbr.2006.02.028

DO - 10.1016/j.bbr.2006.02.028

M3 - Article

SN - 0166-4328

VL - 170

SP - 257

EP - 261

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel

Abstract

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