Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

M. P. M. Adriaanse; A. Mubarak; R. G. Riedl; F. J. W. Ten Kate; J. G. M. C. Damoiseaux; W. A. Buurman; R. H. J. Houwen; A. C. E. Vreugdenhil; Celiac Dis Study Grp

doi:10.1038/s41598-017-07242-4

Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

M. P. M. Adriaanse
, A. Mubarak
, R. G. Riedl
, F. J. W. Ten Kate
, J. G. M. C. Damoiseaux
, W. A. Buurman
, R. H. J. Houwen
, A. C. E. Vreugdenhil^*
, Celiac Dis Study Grp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7%) children with slightly elevated tTG-IgA titres (

Original language	English
Article number	8671
Number of pages	9
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-07242-4
Publication status	Published - 17 Aug 2017

Keywords

VILLOUS ATROPHY
GLUTEN
SENSITIVITY
ANTIBODIES
MARKER
ADULTS
DAMAGE
GENE

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Adriaanse, M. P. M., Mubarak, A., Riedl, R. G., Ten Kate, F. J. W., Damoiseaux, J. G. M. C., Buurman, W. A., Houwen, R. H. J., Vreugdenhil, A. C. E., & Celiac Dis Study Grp (2017). Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Scientific Reports, 7(1), Article 8671. https://doi.org/10.1038/s41598-017-07242-4

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abstract = "This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8\%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7\%) children with slightly elevated tTG-IgA titres (",

keywords = "VILLOUS ATROPHY, GLUTEN, SENSITIVITY, ANTIBODIES, MARKER, ADULTS, DAMAGE, GENE",

author = "Adriaanse, \{M. P. M.\} and A. Mubarak and Riedl, \{R. G.\} and \{Ten Kate\}, \{F. J. W.\} and Damoiseaux, \{J. G. M. C.\} and Buurman, \{W. A.\} and Houwen, \{R. H. J.\} and Vreugdenhil, \{A. C. E.\} and \{Celiac Dis Study Grp\}",

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Adriaanse, MPM, Mubarak, A, Riedl, RG, Ten Kate, FJW, Damoiseaux, JGMC, Buurman, WA, Houwen, RHJ, Vreugdenhil, ACE & Celiac Dis Study Grp 2017, 'Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP', Scientific Reports, vol. 7, no. 1, 8671. https://doi.org/10.1038/s41598-017-07242-4

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AU - Mubarak, A.

AU - Riedl, R. G.

AU - Ten Kate, F. J. W.

AU - Damoiseaux, J. G. M. C.

AU - Buurman, W. A.

AU - Houwen, R. H. J.

AU - Vreugdenhil, A. C. E.

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KW - SENSITIVITY

KW - ANTIBODIES

KW - MARKER

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KW - DAMAGE

KW - GENE

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JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 8671

ER -

Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

Abstract

Keywords

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