Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

M. P. M. Adriaanse; A. Mubarak; R. G. Riedl; F. J. W. Ten Kate; J. G. M. C. Damoiseaux; W. A. Buurman; R. H. J. Houwen; A. C. E. Vreugdenhil; Celiac Dis Study Grp

doi:10.1038/s41598-017-07242-4

Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

M. P. M. Adriaanse, A. Mubarak, R. G. Riedl, F. J. W. Ten Kate, J. G. M. C. Damoiseaux, W. A. Buurman, R. H. J. Houwen, A. C. E. Vreugdenhil^*, Celiac Dis Study Grp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7%) children with slightly elevated tTG-IgA titres (

Original language	English
Article number	8671
Number of pages	9
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-07242-4
Publication status	Published - 17 Aug 2017

Keywords

VILLOUS ATROPHY
GLUTEN
SENSITIVITY
ANTIBODIES
MARKER
ADULTS
DAMAGE
GENE

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Adriaanse, M. P. M., Mubarak, A., Riedl, R. G., Ten Kate, F. J. W., Damoiseaux, J. G. M. C., Buurman, W. A., Houwen, R. H. J., Vreugdenhil, A. C. E., & Celiac Dis Study Grp (2017). Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP. Scientific Reports, 7(1), Article 8671. https://doi.org/10.1038/s41598-017-07242-4

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abstract = "This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7%) children with slightly elevated tTG-IgA titres (",

keywords = "VILLOUS ATROPHY, GLUTEN, SENSITIVITY, ANTIBODIES, MARKER, ADULTS, DAMAGE, GENE",

author = "Adriaanse, {M. P. M.} and A. Mubarak and Riedl, {R. G.} and {Ten Kate}, {F. J. W.} and Damoiseaux, {J. G. M. C.} and Buurman, {W. A.} and Houwen, {R. H. J.} and Vreugdenhil, {A. C. E.} and {Celiac Dis Study Grp}",

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Adriaanse, MPM, Mubarak, A, Riedl, RG, Ten Kate, FJW, Damoiseaux, JGMC, Buurman, WA, Houwen, RHJ, Vreugdenhil, ACE & Celiac Dis Study Grp 2017, 'Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP', Scientific Reports, vol. 7, no. 1, 8671. https://doi.org/10.1038/s41598-017-07242-4

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AU - Ten Kate, F. J. W.

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KW - ANTIBODIES

KW - MARKER

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Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

Abstract

Keywords

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