Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

M. P. M. Adriaanse, A. Mubarak, R. G. Riedl, F. J. W. Ten Kate, J. G. M. C. Damoiseaux, W. A. Buurman, R. H. J. Houwen, A. C. E. Vreugdenhil*, Celiac Dis Study Grp

*Corresponding author for this work

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Abstract

This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7%) children with slightly elevated tTG-IgA titres (

Original languageEnglish
Article number8671
Number of pages9
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 17 Aug 2017

Keywords

  • VILLOUS ATROPHY
  • GLUTEN
  • SENSITIVITY
  • ANTIBODIES
  • MARKER
  • ADULTS
  • DAMAGE
  • GENE

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