Abstract
Introduction: Bipolar disorder (BD) is a considerable burden to the affected individual. The need for novel drug targets and improved drug design (DD) in BD is therefore clear. Areas covered: The following article provides a brief, narrative, clinician-oriented overview of the most promising novel pharmacological targets for BD along with a concise overview regarding the general DD process and the unmet needs relevant to BD. Expert opinion: A number of novel potential drug targets have been investigated. With the notable exception of the kynurenine pathway, available evidence is too scarce to highlight a definitive roadmap for forthcoming DD in BD. BD itself may present with different facets, as it is a polymorphic clinical spectrum. Therefore, promoting clinical-case stratification should be based on precision medicine, rather than on novel biological targets. Furthermore, the full release of raw study data to the scientific community and the development of uniform clinical trial standards (including more realistic outcomes) should be promoted to facilitate the DD process in BD.
Original language | English |
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Pages (from-to) | 221-228 |
Number of pages | 8 |
Journal | Expert Opinion on Drug Discovery |
Volume | 13 |
Issue number | 3 |
DOIs | |
Publication status | Published - 22 Jan 2018 |
Keywords
- Bipolar disorder (BD)
- drug design
- novel therapeutic targets
- PLACEBO-CONTROLLED TRIAL
- RANDOMIZED CONTROLLED-TRIALS
- GLYCOGEN-SYNTHASE KINASE-3
- ADJUNCTIVE THERAPY
- DOUBLE-BLIND
- INTERNATIONAL SOCIETY
- ANTIDEPRESSANT DRUGS
- ALZHEIMERS-DISEASE
- ANXIETY DISORDERS
- CIRCADIAN GENES