Progress and perspectives in plant sterol and plant stanol research

Peter J. H. Jones; Maryam Shamloo; Dylan S. MacKay; Todd C. Rideout; Semone B. Myrie; Jogchum Plat; Jean-Baptiste Roullet; David J. Baer; Kara L. Calkins; Harry R. Davis; P. Barton Duell; Henry Ginsberg; Helena Gylling; David Jenkins; Dieter Luetjohann; Mohammad Moghadasian; Robert A. Moreau; David Mymin; Richard E. Ostlund; Rouyanne T. Ras; Javier Ochoa Reparaz; Elke A. Trautwein; Stephen Turley; Tim Vanmierlo; Oliver Weingaetner

doi:10.1093/nutrit/nuy032

Progress and perspectives in plant sterol and plant stanol research

Peter J. H. Jones^*, Maryam Shamloo, Dylan S. MacKay, Todd C. Rideout, Semone B. Myrie, Jogchum Plat, Jean-Baptiste Roullet, David J. Baer, Kara L. Calkins, Harry R. Davis, P. Barton Duell, Henry Ginsberg, Helena Gylling, David Jenkins, Dieter Luetjohann, Mohammad Moghadasian, Robert A. Moreau, David Mymin, Richard E. Ostlund, Rouyanne T. RasJavier Ochoa Reparaz, Elke A. Trautwein, Stephen Turley, Tim Vanmierlo, Oliver Weingaetner

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

32 Citations (Web of Science)

Abstract

Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

Original language	English
Pages (from-to)	725-746
Number of pages	22
Journal	Nutrition Reviews
Volume	76
Issue number	10
DOIs	https://doi.org/10.1093/nutrit/nuy032
Publication status	Published - Oct 2018

Keywords

cholesterol
nutrition
plant sterols
plant stanols
sitosterolemia
NON-CHOLESTEROL STEROLS
CORONARY-HEART-DISEASE
CENTRAL-NERVOUS-SYSTEM
BLOOD-BRAIN-BARRIER
HMG-COA REDUCTASE
LDL-CHOLESTEROL
SERUM-LIPIDS
ENDOTHELIAL FUNCTION
HIGH-RISK
VASCULAR FUNCTION

Access to Document

10.1093/nutrit/nuy032

Cite this

Jones, P. J. H., Shamloo, M., MacKay, D. S., Rideout, T. C., Myrie, S. B., Plat, J., Roullet, J-B., Baer, D. J., Calkins, K. L., Davis, H. R., Duell, P. B., Ginsberg, H., Gylling, H., Jenkins, D., Luetjohann, D., Moghadasian, M., Moreau, R. A., Mymin, D., Ostlund, R. E., ... Weingaetner, O. (2018). Progress and perspectives in plant sterol and plant stanol research. Nutrition Reviews, 76(10), 725-746. https://doi.org/10.1093/nutrit/nuy032

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title = "Progress and perspectives in plant sterol and plant stanol research",

abstract = "Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.",

keywords = "cholesterol, nutrition, plant sterols, plant stanols, sitosterolemia, NON-CHOLESTEROL STEROLS, CORONARY-HEART-DISEASE, CENTRAL-NERVOUS-SYSTEM, BLOOD-BRAIN-BARRIER, HMG-COA REDUCTASE, LDL-CHOLESTEROL, SERUM-LIPIDS, ENDOTHELIAL FUNCTION, HIGH-RISK, VASCULAR FUNCTION",

author = "Jones, {Peter J. H.} and Maryam Shamloo and MacKay, {Dylan S.} and Rideout, {Todd C.} and Myrie, {Semone B.} and Jogchum Plat and Jean-Baptiste Roullet and Baer, {David J.} and Calkins, {Kara L.} and Davis, {Harry R.} and Duell, {P. Barton} and Henry Ginsberg and Helena Gylling and David Jenkins and Dieter Luetjohann and Mohammad Moghadasian and Moreau, {Robert A.} and David Mymin and Ostlund, {Richard E.} and Ras, {Rouyanne T.} and Reparaz, {Javier Ochoa} and Trautwein, {Elke A.} and Stephen Turley and Tim Vanmierlo and Oliver Weingaetner",

year = "2018",

month = oct,

doi = "10.1093/nutrit/nuy032",

language = "English",

volume = "76",

pages = "725--746",

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Jones, PJH, Shamloo, M, MacKay, DS, Rideout, TC, Myrie, SB, Plat, J, Roullet, J-B, Baer, DJ, Calkins, KL, Davis, HR, Duell, PB, Ginsberg, H, Gylling, H, Jenkins, D, Luetjohann, D, Moghadasian, M, Moreau, RA, Mymin, D, Ostlund, RE, Ras, RT, Reparaz, JO, Trautwein, EA, Turley, S, Vanmierlo, T & Weingaetner, O 2018, 'Progress and perspectives in plant sterol and plant stanol research', Nutrition Reviews, vol. 76, no. 10, pp. 725-746. https://doi.org/10.1093/nutrit/nuy032

TY - JOUR

T1 - Progress and perspectives in plant sterol and plant stanol research

AU - Jones, Peter J. H.

AU - Shamloo, Maryam

AU - MacKay, Dylan S.

AU - Rideout, Todd C.

AU - Myrie, Semone B.

AU - Plat, Jogchum

AU - Roullet, Jean-Baptiste

AU - Baer, David J.

AU - Calkins, Kara L.

AU - Davis, Harry R.

AU - Duell, P. Barton

AU - Ginsberg, Henry

AU - Gylling, Helena

AU - Jenkins, David

AU - Luetjohann, Dieter

AU - Moghadasian, Mohammad

AU - Moreau, Robert A.

AU - Mymin, David

AU - Ostlund, Richard E.

AU - Ras, Rouyanne T.

AU - Reparaz, Javier Ochoa

AU - Trautwein, Elke A.

AU - Turley, Stephen

AU - Vanmierlo, Tim

AU - Weingaetner, Oliver

PY - 2018/10

Y1 - 2018/10

N2 - Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

AB - Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

KW - cholesterol

KW - nutrition

KW - plant sterols

KW - plant stanols

KW - sitosterolemia

KW - NON-CHOLESTEROL STEROLS

KW - CORONARY-HEART-DISEASE

KW - CENTRAL-NERVOUS-SYSTEM

KW - BLOOD-BRAIN-BARRIER

KW - HMG-COA REDUCTASE

KW - LDL-CHOLESTEROL

KW - SERUM-LIPIDS

KW - ENDOTHELIAL FUNCTION

KW - HIGH-RISK

KW - VASCULAR FUNCTION

U2 - 10.1093/nutrit/nuy032

DO - 10.1093/nutrit/nuy032

M3 - Review article

VL - 76

SP - 725

EP - 746

JO - Nutrition Reviews

JF - Nutrition Reviews

SN - 0029-6643

IS - 10

ER -