Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia

Daniela Galimberti; Bernardo Dell'Osso; Chiara Fenoglio; Chiara Villa; Francesca Cortini; Maria Serpente; Sarah Kittel-Schneider; Johannes Weigl; Maria Neuner; Juliane Volkert; Christine Leonhard; David G. Olmes; Juliane Kopf; Claudia Cantoni; Elisa Ridolfi; Carlotta Palazzo; Laura Ghezzi; Nereo Bresolin; A. C. Altamura; Elio Scarpini; Andreas Reif

doi:10.1371/journal.pone.0032164

Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia

Daniela Galimberti^*, Bernardo Dell'Osso, Chiara Fenoglio, Chiara Villa, Francesca Cortini, Maria Serpente, Sarah Kittel-Schneider, Johannes Weigl, Maria Neuner, Juliane Volkert, Christine Leonhard, David G. Olmes, Juliane Kopf, Claudia Cantoni, Elisa Ridolfi, Carlotta Palazzo, Laura Ghezzi, Nereo Bresolin, A. C. Altamura, Elio ScarpiniAndreas Reif

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n?=?271) or BPD (n?=?237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls.A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P

Original language	English
Article number	e32164
Journal	PLOS ONE
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0032164
Publication status	Published - 10 Apr 2012

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10.1371/journal.pone.0032164Licence: CC BY

Cite this

Galimberti, D., Dell'Osso, B., Fenoglio, C., Villa, C., Cortini, F., Serpente, M., Kittel-Schneider, S., Weigl, J., Neuner, M., Volkert, J., Leonhard, C., Olmes, D. G., Kopf, J., Cantoni, C., Ridolfi, E., Palazzo, C., Ghezzi, L., Bresolin, N., Altamura, A. C., ... Reif, A. (2012). Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia. PLOS ONE, 7(4), Article e32164. https://doi.org/10.1371/journal.pone.0032164

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title = "Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia",

abstract = "Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n?=?271) or BPD (n?=?237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls.A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P",

author = "Daniela Galimberti and Bernardo Dell'Osso and Chiara Fenoglio and Chiara Villa and Francesca Cortini and Maria Serpente and Sarah Kittel-Schneider and Johannes Weigl and Maria Neuner and Juliane Volkert and Christine Leonhard and Olmes, {David G.} and Juliane Kopf and Claudia Cantoni and Elisa Ridolfi and Carlotta Palazzo and Laura Ghezzi and Nereo Bresolin and Altamura, {A. C.} and Elio Scarpini and Andreas Reif",

year = "2012",

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Galimberti, D, Dell'Osso, B, Fenoglio, C, Villa, C, Cortini, F, Serpente, M, Kittel-Schneider, S, Weigl, J, Neuner, M, Volkert, J, Leonhard, C, Olmes, DG, Kopf, J, Cantoni, C, Ridolfi, E, Palazzo, C, Ghezzi, L, Bresolin, N, Altamura, AC, Scarpini, E & Reif, A 2012, 'Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia', PLOS ONE, vol. 7, no. 4, e32164. https://doi.org/10.1371/journal.pone.0032164

TY - JOUR

T1 - Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia

AU - Galimberti, Daniela

AU - Dell'Osso, Bernardo

AU - Fenoglio, Chiara

AU - Villa, Chiara

AU - Cortini, Francesca

AU - Serpente, Maria

AU - Kittel-Schneider, Sarah

AU - Weigl, Johannes

AU - Neuner, Maria

AU - Volkert, Juliane

AU - Leonhard, Christine

AU - Olmes, David G.

AU - Kopf, Juliane

AU - Cantoni, Claudia

AU - Ridolfi, Elisa

AU - Palazzo, Carlotta

AU - Ghezzi, Laura

AU - Bresolin, Nereo

AU - Altamura, A. C.

AU - Scarpini, Elio

AU - Reif, Andreas

PY - 2012/4/10

Y1 - 2012/4/10

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AB - Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n?=?271) or BPD (n?=?237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls.A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P

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