Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia

Daniela Galimberti*, Bernardo Dell'Osso, Chiara Fenoglio, Chiara Villa, Francesca Cortini, Maria Serpente, Sarah Kittel-Schneider, Johannes Weigl, Maria Neuner, Juliane Volkert, Christine Leonhard, David G. Olmes, Juliane Kopf, Claudia Cantoni, Elisa Ridolfi, Carlotta Palazzo, Laura Ghezzi, Nereo Bresolin, A. C. Altamura, Elio ScarpiniAndreas Reif

*Corresponding author for this work

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Abstract

Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n?=?271) or BPD (n?=?237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls.A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P
Original languageEnglish
Article numbere32164
JournalPLOS ONE
Volume7
Issue number4
DOIs
Publication statusPublished - 10 Apr 2012

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