Abstract
In addition to the six-min walk distance (6 MWD), other six-min walk test (6 MWT) derived variables, such as mean walk-speed (6MWSpeed), 6-min walk-work (6 MWW), distance-saturation product (DSP), exercise-induced oxygen desaturation (EID), and unintended stops may be useful for the prediction of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). We studied the association between 6 MWT-derived variables and mortality as well as hospitalization in COPD patients and compared it with the BODE index. A three-year prospective study (ECLIPSE) to evaluate the prognostic value of 6 MWT-derived variables in 2010 COPD patients. Cox's proportional-hazard regressions were performed to estimate 3-year mortality and hospitalization. During the follow-up, 193 subjects died and 622 were hospitalized. An adjusted Cox's regression model of hazard ratio [HR] for impaired 6 MWT-derived variables was significant referring to: mortality (6 MWD </=334 m [2.30], 6MWSpeed </=0.9 m/sec [2.15], 6 MWW </=20000 m kg [2.17], DSP </=290 m% [2.70], EID </=88% [1.75], unintended stops [1.99]; and hospitalization (6 MWW </=27000 m kg [1.23], EID </=88% [1.25], BODE index >/=3 points [1.40]; all p </= 0.05). The 6 MWT-derived variables have an additional predictive value of mortality in patients with COPD. The 6 MWW, EID and the BODE index refine the prognosis of hospitalization.
Original language | English |
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Pages (from-to) | 1138-1146 |
Number of pages | 9 |
Journal | Respiratory Medicine |
Volume | 109 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2015 |
Keywords
- Exercise testing
- Exercise physiology
- Prognostic markers
- Mortality
- Hospitalization
- COPD
- OBSTRUCTIVE PULMONARY-DISEASE
- CHRONIC RESPIRATORY-DISEASE
- GAIT SPEED
- FUNCTIONAL-CAPACITY
- OXYGEN DESATURATION
- OLDER-ADULTS
- BODE INDEX
- DISTANCE
- MORTALITY
- HOSPITALIZATION