Prognostic Value of the Change in Heart Rate From the Supine to the Upright Position in Patients With Chronic Heart Failure

Micha T. Maeder; Marzena Zurek; Hans Rickli; Daniel Tobler; Stephanie Kiencke; Thomas Suter; Se-Il Yoon; Barbara Julius; Matthias E. Pfisterer; Hanspeter Brunner-La Rocca

doi:10.1161/JAHA.116.003524

Prognostic Value of the Change in Heart Rate From the Supine to the Upright Position in Patients With Chronic Heart Failure

Micha T. Maeder^*, Marzena Zurek, Hans Rickli, Daniel Tobler, Stephanie Kiencke, Thomas Suter, Se-Il Yoon, Barbara Julius, Matthias E. Pfisterer, Hanspeter Brunner-La Rocca

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background-The prognostic value of the change in heart rate from the supine to upright position (Delta HR) in patients with chronic heart failure (HF) is unknown. Methods and Results-Delta HR was measured in patients enrolled in the Trial of Intensified Medical Therapy in Elderly Patients with Congestive Heart Failure (TIME-CHF) who were in sinus rhythm and had no pacemaker throughout the trial (n=321). The impact of Delta HR on 18-month outcome (HF hospitalization-free survival) was assessed. In addition, the prognostic effect of changes in Delta HR between baseline and month 6 on outcomes in the following 12 months was determined. A lower Delta HR was associated with a higher risk of death or HF hospitalization (hazard ratio 1.79 [95% confidence interval {95% CI} 1.19-2.75] if Delta HR

Original language	English
Article number	e003524
Journal	Journal of the American Heart Association
Volume	5
Issue number	8
DOIs	https://doi.org/10.1161/JAHA.116.003524
Publication status	Published - Aug 2016

Keywords

autonomic nervous system
heart failure
heart rate/heart rate variability
prognosis
TIME-CHF

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Maeder, M. T., Zurek, M., Rickli, H., Tobler, D., Kiencke, S., Suter, T., Yoon, S.-I., Julius, B., Pfisterer, M. E., & Brunner-La Rocca, H. (2016). Prognostic Value of the Change in Heart Rate From the Supine to the Upright Position in Patients With Chronic Heart Failure. Journal of the American Heart Association, 5(8), Article e003524. https://doi.org/10.1161/JAHA.116.003524

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title = "Prognostic Value of the Change in Heart Rate From the Supine to the Upright Position in Patients With Chronic Heart Failure",

abstract = "Background-The prognostic value of the change in heart rate from the supine to upright position (Delta HR) in patients with chronic heart failure (HF) is unknown. Methods and Results-Delta HR was measured in patients enrolled in the Trial of Intensified Medical Therapy in Elderly Patients with Congestive Heart Failure (TIME-CHF) who were in sinus rhythm and had no pacemaker throughout the trial (n=321). The impact of Delta HR on 18-month outcome (HF hospitalization-free survival) was assessed. In addition, the prognostic effect of changes in Delta HR between baseline and month 6 on outcomes in the following 12 months was determined. A lower Delta HR was associated with a higher risk of death or HF hospitalization (hazard ratio 1.79 [95% confidence interval {95% CI} 1.19-2.75] if Delta HR ",

keywords = "autonomic nervous system, heart failure, heart rate/heart rate variability, prognosis, TIME-CHF",

author = "Maeder, {Micha T.} and Marzena Zurek and Hans Rickli and Daniel Tobler and Stephanie Kiencke and Thomas Suter and Se-Il Yoon and Barbara Julius and Pfisterer, {Matthias E.} and {Brunner-La Rocca}, Hanspeter",

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AU - Maeder, Micha T.

AU - Zurek, Marzena

AU - Rickli, Hans

AU - Tobler, Daniel

AU - Kiencke, Stephanie

AU - Suter, Thomas

AU - Yoon, Se-Il

AU - Julius, Barbara

AU - Pfisterer, Matthias E.

AU - Brunner-La Rocca, Hanspeter

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AB - Background-The prognostic value of the change in heart rate from the supine to upright position (Delta HR) in patients with chronic heart failure (HF) is unknown. Methods and Results-Delta HR was measured in patients enrolled in the Trial of Intensified Medical Therapy in Elderly Patients with Congestive Heart Failure (TIME-CHF) who were in sinus rhythm and had no pacemaker throughout the trial (n=321). The impact of Delta HR on 18-month outcome (HF hospitalization-free survival) was assessed. In addition, the prognostic effect of changes in Delta HR between baseline and month 6 on outcomes in the following 12 months was determined. A lower Delta HR was associated with a higher risk of death or HF hospitalization (hazard ratio 1.79 [95% confidence interval {95% CI} 1.19-2.75] if Delta HR

KW - autonomic nervous system

KW - heart failure

KW - heart rate/heart rate variability

KW - prognosis

KW - TIME-CHF

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DO - 10.1161/JAHA.116.003524

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SN - 2047-9980

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JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 8

M1 - e003524

ER -

Prognostic Value of the Change in Heart Rate From the Supine to the Upright Position in Patients With Chronic Heart Failure

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Keywords

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