Prognostic Value of Reading-to-Reading Blood Pressure Variability Over 24 Hours in 8938 Subjects From 11 Populations

Tine W. Hansen; Lutgarde Thijs; Yan Li; Jose Boggia; Masahiro Kikuya; Kristina Bjorklund-Bodegard; Tom Richart; Takayoshi Ohkubo; Jorgen Jeppesen; Christian Torp-Pedersen; Eamon Dolan; Tatiana Kuznetsova; Katarzyna Stolarz-Skrzypek; Valerie Tikhonoff; Sofia Malyutina; Edoardo Casiglia; Yuri Nikitin; Lars Lind; Edgardo Sandoya; Kalina Kawecka-Jaszcz; Yutaka Imai; Jiguang Wang; Hans Ibsen; Eoin O'Brien; Jan A. Staessen

doi:10.1161/HYPERTENSIONAHA.109.140798

Prognostic Value of Reading-to-Reading Blood Pressure Variability Over 24 Hours in 8938 Subjects From 11 Populations

Tine W. Hansen, Lutgarde Thijs, Yan Li, Jose Boggia, Masahiro Kikuya, Kristina Bjorklund-Bodegard, Tom Richart, Takayoshi Ohkubo, Jorgen Jeppesen, Christian Torp-Pedersen, Eamon Dolan, Tatiana Kuznetsova, Katarzyna Stolarz-Skrzypek, Valerie Tikhonoff, Sofia Malyutina, Edoardo Casiglia, Yuri Nikitin, Lars Lind, Edgardo Sandoya, Kalina Kawecka-JaszczYutaka Imai, Jiguang Wang, Hans Ibsen, Eoin O'Brien, Jan A. Staessen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (P = 1.07) with the exception of cardiac and coronary events (HR: = 0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (P= 1.07), with the exception of cardiac and coronary events (HR: = 0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added

Original language	English
Pages (from-to)	1049-U419
Journal	Hypertension
Volume	55
Issue number	4
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.109.140798
Publication status	Published - Apr 2010

Keywords

blood pressure variability
ambulatory blood pressure
population science
risk factors
epidemiology

Access to Document

10.1161/HYPERTENSIONAHA.109.140798

Cite this

Hansen, T. W., Thijs, L., Li, Y., Boggia, J., Kikuya, M., Bjorklund-Bodegard, K., Richart, T., Ohkubo, T., Jeppesen, J., Torp-Pedersen, C., Dolan, E., Kuznetsova, T., Stolarz-Skrzypek, K., Tikhonoff, V., Malyutina, S., Casiglia, E., Nikitin, Y., Lind, L., Sandoya, E., ... Staessen, J. A. (2010). Prognostic Value of Reading-to-Reading Blood Pressure Variability Over 24 Hours in 8938 Subjects From 11 Populations. Hypertension, 55(4), 1049-U419. https://doi.org/10.1161/HYPERTENSIONAHA.109.140798

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abstract = "In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (P = 1.07) with the exception of cardiac and coronary events (HR: = 0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (P= 1.07), with the exception of cardiac and coronary events (HR: = 0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added ",

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author = "Hansen, {Tine W.} and Lutgarde Thijs and Yan Li and Jose Boggia and Masahiro Kikuya and Kristina Bjorklund-Bodegard and Tom Richart and Takayoshi Ohkubo and Jorgen Jeppesen and Christian Torp-Pedersen and Eamon Dolan and Tatiana Kuznetsova and Katarzyna Stolarz-Skrzypek and Valerie Tikhonoff and Sofia Malyutina and Edoardo Casiglia and Yuri Nikitin and Lars Lind and Edgardo Sandoya and Kalina Kawecka-Jaszcz and Yutaka Imai and Jiguang Wang and Hans Ibsen and Eoin O'Brien and Staessen, {Jan A.}",

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doi = "10.1161/HYPERTENSIONAHA.109.140798",

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Hansen, TW, Thijs, L, Li, Y, Boggia, J, Kikuya, M, Bjorklund-Bodegard, K, Richart, T, Ohkubo, T, Jeppesen, J, Torp-Pedersen, C, Dolan, E, Kuznetsova, T, Stolarz-Skrzypek, K, Tikhonoff, V, Malyutina, S, Casiglia, E, Nikitin, Y, Lind, L, Sandoya, E, Kawecka-Jaszcz, K, Imai, Y, Wang, J, Ibsen, H, O'Brien, E & Staessen, JA 2010, 'Prognostic Value of Reading-to-Reading Blood Pressure Variability Over 24 Hours in 8938 Subjects From 11 Populations', Hypertension, vol. 55, no. 4, pp. 1049-U419. https://doi.org/10.1161/HYPERTENSIONAHA.109.140798

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T1 - Prognostic Value of Reading-to-Reading Blood Pressure Variability Over 24 Hours in 8938 Subjects From 11 Populations

AU - Hansen, Tine W.

AU - Thijs, Lutgarde

AU - Li, Yan

AU - Boggia, Jose

AU - Kikuya, Masahiro

AU - Bjorklund-Bodegard, Kristina

AU - Richart, Tom

AU - Ohkubo, Takayoshi

AU - Jeppesen, Jorgen

AU - Torp-Pedersen, Christian

AU - Dolan, Eamon

AU - Kuznetsova, Tatiana

AU - Stolarz-Skrzypek, Katarzyna

AU - Tikhonoff, Valerie

AU - Malyutina, Sofia

AU - Casiglia, Edoardo

AU - Nikitin, Yuri

AU - Lind, Lars

AU - Sandoya, Edgardo

AU - Kawecka-Jaszcz, Kalina

AU - Imai, Yutaka

AU - Wang, Jiguang

AU - Ibsen, Hans

AU - O'Brien, Eoin

AU - Staessen, Jan A.

PY - 2010/4

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N2 - In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (P = 1.07) with the exception of cardiac and coronary events (HR: = 0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (P= 1.07), with the exception of cardiac and coronary events (HR: = 0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added

AB - In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (P = 1.07) with the exception of cardiac and coronary events (HR: = 0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (P= 1.07), with the exception of cardiac and coronary events (HR: = 0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added

KW - blood pressure variability

KW - ambulatory blood pressure

KW - population science

KW - risk factors

KW - epidemiology

U2 - 10.1161/HYPERTENSIONAHA.109.140798

DO - 10.1161/HYPERTENSIONAHA.109.140798

M3 - Article

C2 - 20212270

SN - 0194-911X

VL - 55

SP - 1049-U419

JO - Hypertension

JF - Hypertension

IS - 4

ER -