Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography

Lars Gunnar Klaeboe; Trine F. Haland; Ida S. Leren; Rachel M. A. ter Bekke; Pal H. Brekke; Helge Rosjo; Torbjorn Omland; Lars Gullestad; Svend Aakhus; Kristina H. Haugaa; Thor Edvardsen

doi:10.1016/j.echo.2017.04.009

Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography

Lars Gunnar Klaeboe
, Trine F. Haland
, Ida S. Leren
, Rachel M. A. ter Bekke
, Pal H. Brekke
, Helge Rosjo
, Torbjorn Omland
, Lars Gullestad
, Svend Aakhus
, Kristina H. Haugaa
, Thor Edvardsen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).

Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.

Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [P

Conclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.

Original language	English
Pages (from-to)	727-735.e1
Number of pages	10
Journal	Journal of the American Society of Echocardiography
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.echo.2017.04.009
Publication status	Published - Aug 2017

Keywords

Aortic stenosis
Speckle-tracking echocardiography
Risk assessment
Ventricular function
PRESERVED EJECTION FRACTION
GLOBAL LONGITUDINAL STRAIN
ALL-CAUSE MORTALITY
MYOCARDIAL-INFARCTION
VALVE-REPLACEMENT
MECHANICAL DISPERSION
RISK PREDICTION
ARRHYTHMIAS
CARDIOMYOPATHY
DYSFUNCTION

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Klaeboe, L. G., Haland, T. F., Leren, I. S., ter Bekke, R. M. A., Brekke, P. H., Rosjo, H., Omland, T., Gullestad, L., Aakhus, S., Haugaa, K. H., & Edvardsen, T. (2017). Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography. Journal of the American Society of Echocardiography, 30(8), 727-735.e1. https://doi.org/10.1016/j.echo.2017.04.009

@article{58d219a40772427b9054df0c883225d7,

title = "Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography",

abstract = "Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11\% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [PConclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.",

keywords = "Aortic stenosis, Speckle-tracking echocardiography, Risk assessment, Ventricular function, PRESERVED EJECTION FRACTION, GLOBAL LONGITUDINAL STRAIN, ALL-CAUSE MORTALITY, MYOCARDIAL-INFARCTION, VALVE-REPLACEMENT, MECHANICAL DISPERSION, RISK PREDICTION, ARRHYTHMIAS, CARDIOMYOPATHY, DYSFUNCTION",

author = "Klaeboe, \{Lars Gunnar\} and Haland, \{Trine F.\} and Leren, \{Ida S.\} and \{ter Bekke\}, \{Rachel M. A.\} and Brekke, \{Pal H.\} and Helge Rosjo and Torbjorn Omland and Lars Gullestad and Svend Aakhus and Haugaa, \{Kristina H.\} and Thor Edvardsen",

year = "2017",

month = aug,

doi = "10.1016/j.echo.2017.04.009",

language = "English",

volume = "30",

pages = "727--735.e1",

journal = "Journal of the American Society of Echocardiography",

issn = "0894-7317",

publisher = "Elsevier Inc.",

number = "8",

}

Klaeboe, LG, Haland, TF, Leren, IS, ter Bekke, RMA, Brekke, PH, Rosjo, H, Omland, T, Gullestad, L, Aakhus, S, Haugaa, KH & Edvardsen, T 2017, 'Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography', Journal of the American Society of Echocardiography, vol. 30, no. 8, pp. 727-735.e1. https://doi.org/10.1016/j.echo.2017.04.009

Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography. / Klaeboe, Lars Gunnar; Haland, Trine F.; Leren, Ida S. et al.
In: Journal of the American Society of Echocardiography, Vol. 30, No. 8, 08.2017, p. 727-735.e1.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis

T2 - A Pilot Study of the Usefulness of Strain Echocardiography

AU - Klaeboe, Lars Gunnar

AU - Haland, Trine F.

AU - Leren, Ida S.

AU - ter Bekke, Rachel M. A.

AU - Brekke, Pal H.

AU - Rosjo, Helge

AU - Omland, Torbjorn

AU - Gullestad, Lars

AU - Aakhus, Svend

AU - Haugaa, Kristina H.

AU - Edvardsen, Thor

PY - 2017/8

Y1 - 2017/8

N2 - Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [PConclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.

AB - Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [PConclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.

KW - Aortic stenosis

KW - Speckle-tracking echocardiography

KW - Risk assessment

KW - Ventricular function

KW - PRESERVED EJECTION FRACTION

KW - GLOBAL LONGITUDINAL STRAIN

KW - ALL-CAUSE MORTALITY

KW - MYOCARDIAL-INFARCTION

KW - VALVE-REPLACEMENT

KW - MECHANICAL DISPERSION

KW - RISK PREDICTION

KW - ARRHYTHMIAS

KW - CARDIOMYOPATHY

KW - DYSFUNCTION

U2 - 10.1016/j.echo.2017.04.009

DO - 10.1016/j.echo.2017.04.009

M3 - Article

C2 - 28599826

SN - 0894-7317

VL - 30

SP - 727-735.e1

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

IS - 8

ER -

Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography

Abstract

Keywords

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