Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography

Lars Gunnar Klaeboe; Trine F. Haland; Ida S. Leren; Rachel M. A. ter Bekke; Pal H. Brekke; Helge Rosjo; Torbjorn Omland; Lars Gullestad; Svend Aakhus; Kristina H. Haugaa; Thor Edvardsen

doi:10.1016/j.echo.2017.04.009

Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography

Lars Gunnar Klaeboe, Trine F. Haland, Ida S. Leren, Rachel M. A. ter Bekke, Pal H. Brekke, Helge Rosjo, Torbjorn Omland, Lars Gullestad, Svend Aakhus, Kristina H. Haugaa, Thor Edvardsen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).

Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.

Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [P

Conclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.

Original language	English
Pages (from-to)	727-735.e1
Number of pages	10
Journal	Journal of the American Society of Echocardiography
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.echo.2017.04.009
Publication status	Published - Aug 2017

Keywords

Aortic stenosis
Speckle-tracking echocardiography
Risk assessment
Ventricular function
PRESERVED EJECTION FRACTION
GLOBAL LONGITUDINAL STRAIN
ALL-CAUSE MORTALITY
MYOCARDIAL-INFARCTION
VALVE-REPLACEMENT
MECHANICAL DISPERSION
RISK PREDICTION
ARRHYTHMIAS
CARDIOMYOPATHY
DYSFUNCTION

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Cite this

Klaeboe, L. G., Haland, T. F., Leren, I. S., ter Bekke, R. M. A., Brekke, P. H., Rosjo, H., Omland, T., Gullestad, L., Aakhus, S., Haugaa, K. H., & Edvardsen, T. (2017). Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography. Journal of the American Society of Echocardiography, 30(8), 727-735.e1. https://doi.org/10.1016/j.echo.2017.04.009

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title = "Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography",

abstract = "Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [PConclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.",

keywords = "Aortic stenosis, Speckle-tracking echocardiography, Risk assessment, Ventricular function, PRESERVED EJECTION FRACTION, GLOBAL LONGITUDINAL STRAIN, ALL-CAUSE MORTALITY, MYOCARDIAL-INFARCTION, VALVE-REPLACEMENT, MECHANICAL DISPERSION, RISK PREDICTION, ARRHYTHMIAS, CARDIOMYOPATHY, DYSFUNCTION",

author = "Klaeboe, {Lars Gunnar} and Haland, {Trine F.} and Leren, {Ida S.} and {ter Bekke}, {Rachel M. A.} and Brekke, {Pal H.} and Helge Rosjo and Torbjorn Omland and Lars Gullestad and Svend Aakhus and Haugaa, {Kristina H.} and Thor Edvardsen",

year = "2017",

month = aug,

doi = "10.1016/j.echo.2017.04.009",

language = "English",

volume = "30",

pages = "727--735.e1",

journal = "Journal of the American Society of Echocardiography",

issn = "0894-7317",

publisher = "MOSBY-ELSEVIER",

number = "8",

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Klaeboe, LG, Haland, TF, Leren, IS, ter Bekke, RMA, Brekke, PH, Rosjo, H, Omland, T, Gullestad, L, Aakhus, S, Haugaa, KH & Edvardsen, T 2017, 'Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography', Journal of the American Society of Echocardiography, vol. 30, no. 8, pp. 727-735.e1. https://doi.org/10.1016/j.echo.2017.04.009

Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography. / Klaeboe, Lars Gunnar; Haland, Trine F.; Leren, Ida S. et al.
In: Journal of the American Society of Echocardiography, Vol. 30, No. 8, 08.2017, p. 727-735.e1.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis

T2 - A Pilot Study of the Usefulness of Strain Echocardiography

AU - Klaeboe, Lars Gunnar

AU - Haland, Trine F.

AU - Leren, Ida S.

AU - ter Bekke, Rachel M. A.

AU - Brekke, Pal H.

AU - Rosjo, Helge

AU - Omland, Torbjorn

AU - Gullestad, Lars

AU - Aakhus, Svend

AU - Haugaa, Kristina H.

AU - Edvardsen, Thor

PY - 2017/8

Y1 - 2017/8

N2 - Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [PConclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.

AB - Background: In patients with aortic stenosis, subtle alterations in myocardial mechanics can be detected by speckle-tracking echocardiography before reduction of left ventricular ejection fraction (LVEF).Methods: In this prospective study, 162 patients with aortic stenosis with an average aortic valve area of 0.7 +/- 0.2 cm(2) and a mean LVEF of 60 +/- 11% were included. Global longitudinal strain (GLS) and mechanical dispersion (SD of time from Q/R on the electrocardiogram to peak strain in 16 left ventricular segments) were assessed using echocardiography, and all-causemortality (n=37) was recordedduring37 +/- 13 months of follow-up.Results: Overall, nonsurvivors had more pronounced mechanical dispersion and worse GLS compared with survivors (74 +/- 24 vs 61 +/- 18 msec [PConclusion: Increased mechanical dispersion may be a risk marker providing novel prognostic information in patients with aortic stenosis.

KW - Aortic stenosis

KW - Speckle-tracking echocardiography

KW - Risk assessment

KW - Ventricular function

KW - PRESERVED EJECTION FRACTION

KW - GLOBAL LONGITUDINAL STRAIN

KW - ALL-CAUSE MORTALITY

KW - MYOCARDIAL-INFARCTION

KW - VALVE-REPLACEMENT

KW - MECHANICAL DISPERSION

KW - RISK PREDICTION

KW - ARRHYTHMIAS

KW - CARDIOMYOPATHY

KW - DYSFUNCTION

U2 - 10.1016/j.echo.2017.04.009

DO - 10.1016/j.echo.2017.04.009

M3 - Article

C2 - 28599826

SN - 0894-7317

VL - 30

SP - 727-735.e1

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

IS - 8

ER -