TY - JOUR
T1 - Prognostic value of handgrip strength in people aged 60 years and older: A systematic review and meta-analysis
AU - Rijk, Joke M.
AU - Roos, Paul R. K. M.
AU - Deckx, Laura
AU - van den Akker, Marjan
AU - Buntinx, Frank
PY - 2016/1
Y1 - 2016/1
N2 - Aim The aim of the present study was to systematically review the literature on the predictive value of handgrip strength as a marker for vulnerability. Furthermore, we aimed to update a recent systematic review on the association between handgrip strength and mortality. MethodsLiterature searches using Cochrane, PubMed and Embase databases, and searching reference lists of included studies. Eligible studies were observational longitudinal studies presenting handgrip strength at baseline as an independent variable and its association with cognition, depression, mobility, functional status, hospitalization or mortality at follow up in a general population aged 60 years and older. With respect to mortality, we updated a recent systematic review. ResultsWe included 34 articles. Most of them involved the association between handgrip strength and cognition (n=9), functional status (n=12), mobility (n=6) or mortality (n=22), and mainly found a positive relationship, meaning that higher handgrip strength at baseline is protective for declines in these outcome measures. Statistical pooling was carried out for functional status and mortality, with a pooled ratio for functional status of 1.78 (95% CI 1.28-2.48) for categorical variables (high vs low handgrip strength) and 0.95 (95% CI 0.92-0.99) for handgrip strength as a continuous variable. The pooled hazard ratio for mortality was 1.79 (95% CI 1.26-2.55) for categorical variables and 0.96 (95% CI 0.93-0.98) for continuous variables. ConclusionsHandgrip strength has a predictive validity for decline in cognition, mobility, functional status and mortality in older community-dwelling populations. Geriatr Gerontol Int 2016; 16: 5-20.
AB - Aim The aim of the present study was to systematically review the literature on the predictive value of handgrip strength as a marker for vulnerability. Furthermore, we aimed to update a recent systematic review on the association between handgrip strength and mortality. MethodsLiterature searches using Cochrane, PubMed and Embase databases, and searching reference lists of included studies. Eligible studies were observational longitudinal studies presenting handgrip strength at baseline as an independent variable and its association with cognition, depression, mobility, functional status, hospitalization or mortality at follow up in a general population aged 60 years and older. With respect to mortality, we updated a recent systematic review. ResultsWe included 34 articles. Most of them involved the association between handgrip strength and cognition (n=9), functional status (n=12), mobility (n=6) or mortality (n=22), and mainly found a positive relationship, meaning that higher handgrip strength at baseline is protective for declines in these outcome measures. Statistical pooling was carried out for functional status and mortality, with a pooled ratio for functional status of 1.78 (95% CI 1.28-2.48) for categorical variables (high vs low handgrip strength) and 0.95 (95% CI 0.92-0.99) for handgrip strength as a continuous variable. The pooled hazard ratio for mortality was 1.79 (95% CI 1.26-2.55) for categorical variables and 0.96 (95% CI 0.93-0.98) for continuous variables. ConclusionsHandgrip strength has a predictive validity for decline in cognition, mobility, functional status and mortality in older community-dwelling populations. Geriatr Gerontol Int 2016; 16: 5-20.
KW - aged
KW - functional status
KW - handgrip strength
KW - mortality
KW - review
U2 - 10.1111/ggi.12508
DO - 10.1111/ggi.12508
M3 - Article
C2 - 26016893
SN - 1444-1586
VL - 16
SP - 5
EP - 20
JO - Geriatrics & Gerontology International
JF - Geriatrics & Gerontology International
IS - 1
ER -