TY - JOUR
T1 - Prognostic Factors for the Failure of Endometrial Ablation A Systematic Review and Meta-analysis
AU - Beelen, Pleun
AU - Reinders, Imke M. A.
AU - Scheepers, Wessel F. W.
AU - Herman, Malou C.
AU - Geomini, M. A. J.
AU - van Kuijk, Sander M. J.
AU - Bongers, Marlies Y.
PY - 2019/12
Y1 - 2019/12
N2 - OBJECTIVE: To provide an overview of prognostic factors predicting failure of second-generation endometrial ablation.DATA SOURCES: MEDLINE, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systematically searched from 1988 until February 2019. The search was conducted without language restrictions using the following search terms: "endometrial ablation," "progno-sis," "predict," "long term," "late onset," "outcome."METHODS OF STUDY SELECTION: The literature search provided a total of 990 studies. All types of studies reporting about prognostic factors of second-generation endometrial ablation failure were included.TABULATION, INTEGRATION, AND RESULTS: After screening for eligibility, 56 studies were included in this review, of which 21 were included in the meta-analysis. In these 56 studies, 157,830 women were included. We evaluated 10 prognostic factors: age, myomas, history of tubal ligation, body mass index, parity, preexisting dysmenorrhea, caesarean delivery, bleeding pattern, uterus position, and uterus length. Meta-analysis was performed for the primary outcome (surgical reinterven-tion) to estimate summary treatment effects. Younger age (aged 35 years or younger, odds ratio [OR] 1.68, 95% CI 1.19-2.36; aged 40 years or younger, OR 1.58, 95% CI 1.30-1.93; aged 45 years or younger OR 1.63, 95% CI 1.28-2.07), prior tubal ligation (OR 1.46, 95% CI 1.23-1.73), and preexisting dysmenorrhea (OR 2.12, 95% CI 1.41-3.19) were associated with an increased risk of sur-gical reintervention. Studies investigating the prognostic factors myomas and obesity showed conflicting results.CONCLUSION: Younger age, prior tubal ligation and preexisting dysmenorrhea were found to be associated with failure of endometrial ablation. Obesity and the presence of large submucous myomas may be associated with failure, as well, though more research is necessary to estimate the influence of these factors. It is important to take the results of this review into account when counselling women with heavy menstrual bleeding.
AB - OBJECTIVE: To provide an overview of prognostic factors predicting failure of second-generation endometrial ablation.DATA SOURCES: MEDLINE, EMBASE, the Cochrane Library, and ClinicalTrials.gov were systematically searched from 1988 until February 2019. The search was conducted without language restrictions using the following search terms: "endometrial ablation," "progno-sis," "predict," "long term," "late onset," "outcome."METHODS OF STUDY SELECTION: The literature search provided a total of 990 studies. All types of studies reporting about prognostic factors of second-generation endometrial ablation failure were included.TABULATION, INTEGRATION, AND RESULTS: After screening for eligibility, 56 studies were included in this review, of which 21 were included in the meta-analysis. In these 56 studies, 157,830 women were included. We evaluated 10 prognostic factors: age, myomas, history of tubal ligation, body mass index, parity, preexisting dysmenorrhea, caesarean delivery, bleeding pattern, uterus position, and uterus length. Meta-analysis was performed for the primary outcome (surgical reinterven-tion) to estimate summary treatment effects. Younger age (aged 35 years or younger, odds ratio [OR] 1.68, 95% CI 1.19-2.36; aged 40 years or younger, OR 1.58, 95% CI 1.30-1.93; aged 45 years or younger OR 1.63, 95% CI 1.28-2.07), prior tubal ligation (OR 1.46, 95% CI 1.23-1.73), and preexisting dysmenorrhea (OR 2.12, 95% CI 1.41-3.19) were associated with an increased risk of sur-gical reintervention. Studies investigating the prognostic factors myomas and obesity showed conflicting results.CONCLUSION: Younger age, prior tubal ligation and preexisting dysmenorrhea were found to be associated with failure of endometrial ablation. Obesity and the presence of large submucous myomas may be associated with failure, as well, though more research is necessary to estimate the influence of these factors. It is important to take the results of this review into account when counselling women with heavy menstrual bleeding.
KW - THERMAL BALLOON ABLATION
KW - LONG-TERM OUTCOMES
KW - 5-YEAR FOLLOW-UP
KW - QUALITY-OF-LIFE
KW - MENORRHAGIA
KW - WOMEN
KW - SUCCESS
KW - HYSTERECTOMY
KW - TRIAL
KW - HYDROTHERMABLATOR
U2 - 10.1097/AOG.0000000000003556
DO - 10.1097/AOG.0000000000003556
M3 - Review article
C2 - 31764738
VL - 134
SP - 1269
EP - 1281
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 6
ER -