Prognostic DNA methylation markers for renal cell carcinoma: a systematic review

Sophie C. Joosten, Ivette A. G. Deckers, Maureen J. Aarts, Ann Hoeben, Joep G. van Roermund, Kim M. Smits, Veerle Melotte, Manon van Engeland, Vivianne C. Tjan-Heijnen*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Aim: Despite numerous published prognostic methylation markers for renal cell carcinoma (RCC), none of these have yet changed patient management. Our aim is to systematically review and evaluate the literature on prognostic DNA methylation markers for RCC. Materials & methods: We conducted an exhaustive search of PubMed, EMBASE and MEDLINE up to April 2017 and identified 49 publications. Studies were reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, assessed for their reporting quality using the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) criteria, and were graded to determine the level of evidence (LOE) for each biomarker. Results: We identified promoter methylation of BNC1, SCUBE3, GATA5, SFRP1, GREM1, RASSF1A, PCDH8, LAD1 and NEFH as promising prognostic markers. Extensive methodological heterogeneity across the included studies was observed, which hampers comparability and reproducibility of results, providing a possible explanation why these biomarkers do not reach the clinic. Conclusion: Potential prognostic methylation markers for RCC have been identified, but they require further validation in prospective studies to determine their true clinical value.

Original languageEnglish
Pages (from-to)1243-1257
Number of pages15
JournalEpigenomics
Volume9
Issue number9
DOIs
Publication statusPublished - Sept 2017

Keywords

  • biomarkers
  • DNA methylation
  • kidney cancer
  • prognosis
  • promoter CpG island methylation
  • renal cell carcinoma
  • survival
  • CPG ISLAND METHYLATION
  • INTEGRATED STAGING SYSTEM
  • TUMOR-SUPPRESSOR GENE
  • KIDNEY CANCER
  • PROMOTER METHYLATION
  • EPIGENETIC ALTERATIONS
  • POTENTIAL BIOMARKER
  • ADJUVANT SUNITINIB
  • DISEASE RECURRENCE
  • POOR-PROGNOSIS

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