Prognostic and predictive biomarkers in oesophagogastric cancer

Lindsay Charlotte Hewitt

Research output: ThesisDoctoral ThesisInternal

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Abstract

The standard treatment of patients with stomach or gullet cancer is chemotherapy alone or followed by surgery. However, despite all the discoveries that have been made in the last decade, there is currently no test available in the clinic to find out what approach is best for an individual patient. Our research tried to fill this knowledge gap.
We found out that the presence of immune cells within the tumour can indicate whether a patient will benefit from chemotherapy after surgery. Furthermore, we discovered that the distribution of the tumour cells e.g. whether they are evenly distributed in the tissue or not, can predict whether chemotherapy will work or not. We think that these markers will significantly improve patient treatment decisions in the near future.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Grabsch, Heike, Supervisor
  • Melotte, Veerle, Co-Supervisor
Award date28 Nov 2019
Publisher
Print ISBNs9789463613415
DOIs
Publication statusPublished - 2019

Keywords

  • Stomach cancer
  • gullet cancer
  • survival
  • treatment
  • markers

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