Prognosis following local recurrence after breast conserving treatment in young women with early breast cancer

M. J. C. van der Sangen*, P. M. P. Poortmans, S. W. M. Scheepers, B. M. D. Lemaire, C. L. H. van Berlo, V. C. G. Tjan-Heijnen, A. C. Voogd

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Few studies have focussed on the prognosis of young women with local recurrence (LR) after breast-conserving therapy and the factors that can be used to predict their prognosis. Methods: We studied the outcome and related prognostic factors in 124 patients with an isolated local recurrence in the breast following breast-conserving surgery and radiotherapy for early stage breast cancer diagnosed at the age of 40 years or younger. Results: The median follow-up of the patients after diagnosis of LR was 7.0 years. At 10 years from the date of salvage treatment, the overall survival rate was 73% (95% CI, 63783), the distant recurrence-free survival rate was 61% (95% CI, 53-73), and the local control rate (i.e. survival without subsequent LR or local progression) was 95% (95% CI, 91-99). In the multivariate analysis, the risk of distant metastases also tended to be higher for patients with LR occurring within 5 years after BCT, as compared to patients with LR more than 5 years after BCT (Hazard ratio [HR], 1.89; p = 0.09). A worse distant recurrence-free survival was also observed for patients with a LR measuring more than 2 cm in diameter, compared to those with a LR of 2 cm or smaller (HR, 2.88; p = 0.007), and for patients with a LR causing symptoms or suspicious findings at clinical breast examination, compared to those with a LR detected by breast imaging only (HR 3.70; p = 0.03). Conclusions: These results suggest that early detection of LR after BCT in young women can improve treatment outcome.
Original languageEnglish
Pages (from-to)892-898
JournalEuropean Journal of Surgical Oncology
Issue number8
Publication statusPublished - Aug 2013


  • Breast cancer
  • Breast conservation
  • Local recurrence

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