@article{46e88c4ecb2f4cfa89a3c561346b44d0,
title = "Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups",
abstract = "ObjectiveTo address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium.MethodsWe harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis.ResultsIn a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition.ConclusionsThis study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies.",
keywords = "INDIVIDUAL PARTICIPANT DATA, DEMENTIA, STROKE, METAANALYSIS, HYPERTENSION, STATEMENT",
author = "Lo, {Jessica W.} and Crawford, {John D.} and Desmond, {David W.} and Olivier Godefroy and Hanna Jokinen and Simin Mahinrad and Hee-Joon Bae and Jae-Sung Lim and Sebastian Kohler and Elles Douven and Julie Staals and Christopher Chen and Xin Xu and Chong, {Eddie J.} and Akinyemi, {Rufus O.} and Kalaria, {Rajesh N.} and Adesola Ogunniyi and Melanie Barbay and Martine Roussel and Byung-Chul Lee and Srikanth, {Velandai K.} and Christopher Moran and Nagaendran Kandiah and Chander, {Russell J.} and Behnam Sabayan and Jukema, {J. Wouter} and Susanna Melkas and Timo Erkinjuntti and Henry Brodaty and Regis Bordet and Stephanie Bombois and Hilde Henon and Lipnicki, {Darren M.} and Kochan, {Nicole A.} and Sachdev, {Perminder S.} and Amy Brodtmann and Aleksandra Klimkowicz-Mrowiec and Martin Dichgans and Michael Hoffmann and Thomas Linden and Joanna Wardlaw and Charlotte Cordonnier and Vincent Mok and {Stroke and Cognition (STROKOG) Collaboration}",
note = "Funding Information: J. Lo reports grants from Vincent Fairfax. J. Crawford and D. Desmond report no disclosures relevant to the manuscript. O. Godefroy reports grants from DGOS French (health department). H. Jokinen reports grants from the Clinical Research Institute and the Medical Research Fund of the Helsinki University Hospital. S. Mahinrad, H. Bae, J. Lim, S. K{\"o}hler, E. Douven, and J. Staals report no disclosures relevant to the manuscript. C. Chen reports grants from National Medical Research Council of Singapore during the conduct of the study. X. Xu, E. Chong, R. Akinyemi, R. Kalaria, A. Ogunniyi, M. Barbay, M. Roussel, B. Lee, V. Srikanth, C. Moran, N. Kandiah, R. Chander, B. Sabayan, J. Jukema, S. Melkas, T. Erkinjuntti, H. Brodaty, R. Bordet, S. Bombois, H. H{\'e}non, and D. Lipnicki report no disclosures relevant to the manuscript. N. Kochan reports grants from National Health and Medical Research Council Early Career Fellowship (RG123148). P. Sachdev is on the Advisory Board of Biogen Australia. Go to Neurology.org/N for full disclosures. Funding Information: This work was supported by the Vincent Fairfax Family Foundation (Australia) and the National Health and Medical Research Council of Australia Program Grant. Funding information for individual studies is available from Dryad (appendix T20, doi.org/10.5061/dryad.m517990). Publisher Copyright: {\textcopyright} 2019 American Academy of Neurology.",
year = "2019",
month = dec,
day = "10",
doi = "10.1212/WNL.0000000000008612",
language = "English",
volume = "93",
pages = "E2257--E2271",
journal = "Neurology",
issn = "0028-3878",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "24",
}