Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN

Carmen Veith, Milena Hristova, Karamatullah Danyal, Aida Habibovic, Christopher M. Dustin, John E. McDonough, Bart M. Vanaudenaerde, Michael Kreuter, Marc A. Schneider, Nicolas Kahn, Frederik J. van Schooten, Agnes W. Boots, Albert van der Vliet*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)
Original languageEnglish
Pages (from-to)L356-L367
Number of pages12
JournalAmerican Journal of Physiology-Lung Cellular and Molecular Physiology
Volume320
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • idiopathic pulmonary fibrosis
  • mitochondria
  • NOX4
  • redox signaling
  • SRC
  • IDIOPATHIC PULMONARY-FIBROSIS
  • TGF-BETA
  • OXIDATIVE STRESS
  • NADPH-OXIDASE
  • LUNG FIBROSIS
  • MYOFIBROBLAST DIFFERENTIATION
  • MITOCHONDRIAL-DNA
  • SRC KINASE
  • MIGRATION

Cite this