Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

Eduardo Villamor-Martinez, Maria Pierro, Giacomo Cavallaro, Fabio Mosca, Boris Kramer, Eduardo Villamor*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Web of Science)

Abstract

Probiotic supplementation reduces the risk of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in preterm infants, but it remains to be determined whether this reduction translates into a reduction of other complications. We conducted a systematic review and meta-analysis to evaluate the possible role of probiotics in altering the risk of bronchopulmonary dysplasia (BPD). Fifteen randomized controlled trials (4782 infants; probiotics: 2406) were included. None of the included studies assessed BPD as the primary outcome. Meta-analysis confirmed a significant reduction of NEC (risk ratio (RR) 0.52, 95% confidence interval (CI) 0.33 to 0.81, p = 0.004; random effects model), and an almost significant reduction of LOS (RR 0.82, 95% CI 0.65 to 1.03, p = 0.084). In contrast, meta-analysis could not demonstrate a significant effect of probiotics on BPD, defined either as oxygen dependency at 28 days of life (RR 1.01, 95% CI 0.91 to 1.11, p = 0.900, 6 studies) or at 36 weeks of postmenstrual age (RR 1.07, 95% CI 0.96 to 1.20, p = 0.203, 12 studies). Meta-regression did not show any significant association between the RR for NEC or LOS and the RR for BPD. In conclusion, our results suggest that NEC and LOS prevention by probiotics does not affect the risk of developing BPD in preterm infants.

Original languageEnglish
Article number1197
Number of pages19
JournalNutrients
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 2017

Keywords

  • probiotics
  • bronchopulmonary dysplasia
  • sepsis
  • necrotizing enterocolitis
  • BIRTH-WEIGHT INFANTS
  • PREVENT NECROTIZING ENTEROCOLITIS
  • LATE-ONSET SEPSIS
  • CHRONIC LUNG-DISEASE
  • T-CELLS
  • UPDATED METAANALYSIS
  • PREMATURE-INFANTS
  • OUTCOMES
  • INFLAMMATION
  • MORTALITY

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