Probiotic membrane vesicles: emerging tools for disease treatment

Jari Verbunt; Frank R.M. Stassen

doi:10.20517/mrr.2025.20

Probiotic membrane vesicles: emerging tools for disease treatment

Jari Verbunt, Frank R.M. Stassen^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Probiotics are widely recognized for their health benefits, particularly in disease prevention and treatment. Recent research suggests that their therapeutic effects may be linked to the bacterial membrane vesicles (bMVs) they release. These nanoscale vesicles, secreted during probiotic growth and metabolism, facilitate intercellular communication through efficient material transport and signaling. With their biocompatibility and targeting properties, probiotic bMVs hold promise for medical applications. This review examines their biogenesis, bioactive components, functions, and role in disease treatment, while also discussing future research directions to unlock their full therapeutic potential.

Original language	English
Article number	25
Number of pages	11
Journal	Microbiome Research Reports
Volume	4
Issue number	2
DOIs	https://doi.org/10.20517/mrr.2025.20
Publication status	E-pub ahead of print - 24 Jun 2025

Keywords

bacterial membrane vesicles
Probiotics
therapeutics

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10.20517/mrr.2025.20Licence: CC BY

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title = "Probiotic membrane vesicles: emerging tools for disease treatment",

abstract = "Probiotics are widely recognized for their health benefits, particularly in disease prevention and treatment. Recent research suggests that their therapeutic effects may be linked to the bacterial membrane vesicles (bMVs) they release. These nanoscale vesicles, secreted during probiotic growth and metabolism, facilitate intercellular communication through efficient material transport and signaling. With their biocompatibility and targeting properties, probiotic bMVs hold promise for medical applications. This review examines their biogenesis, bioactive components, functions, and role in disease treatment, while also discussing future research directions to unlock their full therapeutic potential.",

keywords = "bacterial membrane vesicles, Probiotics, therapeutics",

author = "Jari Verbunt and Stassen, \{Frank R.M.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

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AU - Stassen, Frank R.M.

PY - 2025/6/24

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N2 - Probiotics are widely recognized for their health benefits, particularly in disease prevention and treatment. Recent research suggests that their therapeutic effects may be linked to the bacterial membrane vesicles (bMVs) they release. These nanoscale vesicles, secreted during probiotic growth and metabolism, facilitate intercellular communication through efficient material transport and signaling. With their biocompatibility and targeting properties, probiotic bMVs hold promise for medical applications. This review examines their biogenesis, bioactive components, functions, and role in disease treatment, while also discussing future research directions to unlock their full therapeutic potential.

AB - Probiotics are widely recognized for their health benefits, particularly in disease prevention and treatment. Recent research suggests that their therapeutic effects may be linked to the bacterial membrane vesicles (bMVs) they release. These nanoscale vesicles, secreted during probiotic growth and metabolism, facilitate intercellular communication through efficient material transport and signaling. With their biocompatibility and targeting properties, probiotic bMVs hold promise for medical applications. This review examines their biogenesis, bioactive components, functions, and role in disease treatment, while also discussing future research directions to unlock their full therapeutic potential.

KW - bacterial membrane vesicles

KW - Probiotics

KW - therapeutics

U2 - 10.20517/mrr.2025.20

DO - 10.20517/mrr.2025.20

M3 - (Systematic) Review article

VL - 4

JO - Microbiome Research Reports

JF - Microbiome Research Reports

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ER -

Probiotic membrane vesicles: emerging tools for disease treatment

Abstract

Keywords

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