Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish

A.B. Moraes; A.C.V.V. Giacomini; R. Genario; L. Marcon; N. Scolari; B.W. Bueno; K.A. Demin; T.G. Amstislavskaya; T. Strekalova; M.C. Soares; M.S. de Abreu; A.V. Kalueff

doi:10.1016/j.neulet.2020.135591

Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish

A.B. Moraes, A.C.V.V. Giacomini, R. Genario, L. Marcon, N. Scolari, B.W. Bueno, K.A. Demin, T.G. Amstislavskaya, T. Strekalova, M.C. Soares, M.S. de Abreu^*, A.V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Estradiol (17 beta-estradiol, E-2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E-2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 mu g/L of E-2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E-2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E-2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E-2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.

Original language	English
Article number	135591
Number of pages	8
Journal	Neuroscience Letters
Volume	747
DOIs	https://doi.org/10.1016/j.neulet.2020.135591
Publication status	Published - 16 Mar 2021

Keywords

Anxiety
Anxiety-like behavior
Cortisol
Estrogens
Social behavior
DANIO-RERIO
ER-BETA
SEXUAL-BEHAVIOR
FEMALE
ESTROGEN-RECEPTOR-BETA
ESTRADIOL LEVELS
ANXIETY DISORDERS
NONREPRODUCTIVE BEHAVIOR
STRESS
BRAIN

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Moraes, A. B., Giacomini, A. C. V. V., Genario, R., Marcon, L., Scolari, N., Bueno, B. W., Demin, K. A., Amstislavskaya, T. G., Strekalova, T., Soares, M. C., de Abreu, M. S., & Kalueff, A. V. (2021). Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish. Neuroscience Letters, 747, Article 135591. https://doi.org/10.1016/j.neulet.2020.135591

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title = "Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish",

abstract = "Estradiol (17 beta-estradiol, E-2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E-2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 mu g/L of E-2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E-2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E-2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E-2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.",

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author = "A.B. Moraes and A.C.V.V. Giacomini and R. Genario and L. Marcon and N. Scolari and B.W. Bueno and K.A. Demin and T.G. Amstislavskaya and T. Strekalova and M.C. Soares and {de Abreu}, M.S. and A.V. Kalueff",

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AU - Moraes, A.B.

AU - Giacomini, A.C.V.V.

AU - Genario, R.

AU - Marcon, L.

AU - Scolari, N.

AU - Bueno, B.W.

AU - Demin, K.A.

AU - Amstislavskaya, T.G.

AU - Strekalova, T.

AU - Soares, M.C.

AU - de Abreu, M.S.

AU - Kalueff, A.V.

PY - 2021/3/16

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N2 - Estradiol (17 beta-estradiol, E-2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E-2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 mu g/L of E-2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E-2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E-2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E-2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.

AB - Estradiol (17 beta-estradiol, E-2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E-2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 mu g/L of E-2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E-2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E-2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E-2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.

KW - Anxiety

KW - Anxiety-like behavior

KW - Cortisol

KW - Estrogens

KW - Social behavior

KW - DANIO-RERIO

KW - ER-BETA

KW - SEXUAL-BEHAVIOR

KW - FEMALE

KW - ESTROGEN-RECEPTOR-BETA

KW - ESTRADIOL LEVELS

KW - ANXIETY DISORDERS

KW - NONREPRODUCTIVE BEHAVIOR

KW - STRESS

KW - BRAIN

U2 - 10.1016/j.neulet.2020.135591

DO - 10.1016/j.neulet.2020.135591

M3 - Article

C2 - 33359732

SN - 0304-3940

VL - 747

JO - Neuroscience Letters

JF - Neuroscience Letters

M1 - 135591

ER -

Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish

Abstract

Keywords

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