TY - JOUR
T1 - Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer
T2 - a multivariate pooled analysis of individual data
AU - Paesmans, Marianne
AU - Garcia, Camilo
AU - Wong, Ching-Yee Oliver
AU - Patz, Edward F
AU - Komaki, Ritsuko
AU - Eschmann, Susanne
AU - Govindan, Ramaswamy
AU - Vansteenkiste, Johan
AU - Meert, Anne-Pascale
AU - de Jong, Wouter K
AU - Altorki, Nasser Khaled
AU - Higashi, Kotaro
AU - Van Baardwijk, Angela
AU - Borst, Gerben R
AU - Ameye, Lieveke
AU - Lafitte, Jean-Jacques
AU - Berghmans, Thierry
AU - Flamen, Patrick
AU - Rami-Porta, Ramon
AU - Sculier, Jean-Paul
N1 - Copyright ©ERS 2015.
PY - 2015/12
Y1 - 2015/12
N2 - (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (PET) complements conventional imaging for diagnosing and staging lung cancer. Two literature-based meta-analyses suggest that maximum standardised uptake value (SUVmax) on PET has univariate prognostic value in nonsmall cell lung cancer (NSCLC). We analysed individual data pooled from 12 studies to assess the independent prognostic value of binary SUVmax for overall survival.After searching the published literature and identifying unpublished data, study coordinators were contacted and requested to provide data on individual patients. Cox regression models stratified for study were used.Data were collected for 1526 patients (median age 64 years, 60% male, 34% squamous cell carcinoma, 47% adenocarcinoma, 58% stage I-II). The combined univariate hazard ratio for SUVmax was 1.43 (95% CI 1.22-1.66) and nearly identical if the SUV threshold was calculated stratifying for histology. Multivariate analysis of patients with stage I-III disease identified age, stage, tumour size and receipt of surgery as independent prognostic factors; adding SUV (HR 1.58, 95% CI 1.27-1.96) improved the model significantly. The only detected interaction was between SUV and stage IV disease.SUV seems to have independent prognostic value in stage I-III NSCLC, for squamous cell carcinoma and for adenocarcinoma.
AB - (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (PET) complements conventional imaging for diagnosing and staging lung cancer. Two literature-based meta-analyses suggest that maximum standardised uptake value (SUVmax) on PET has univariate prognostic value in nonsmall cell lung cancer (NSCLC). We analysed individual data pooled from 12 studies to assess the independent prognostic value of binary SUVmax for overall survival.After searching the published literature and identifying unpublished data, study coordinators were contacted and requested to provide data on individual patients. Cox regression models stratified for study were used.Data were collected for 1526 patients (median age 64 years, 60% male, 34% squamous cell carcinoma, 47% adenocarcinoma, 58% stage I-II). The combined univariate hazard ratio for SUVmax was 1.43 (95% CI 1.22-1.66) and nearly identical if the SUV threshold was calculated stratifying for histology. Multivariate analysis of patients with stage I-III disease identified age, stage, tumour size and receipt of surgery as independent prognostic factors; adding SUV (HR 1.58, 95% CI 1.27-1.96) improved the model significantly. The only detected interaction was between SUV and stage IV disease.SUV seems to have independent prognostic value in stage I-III NSCLC, for squamous cell carcinoma and for adenocarcinoma.
KW - Adenocarcinoma
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Non-Small-Cell Lung
KW - Carcinoma, Squamous Cell
KW - Female
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Lung Neoplasms
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Neoplasm Staging
KW - Positron-Emission Tomography
KW - Prognosis
KW - Proportional Hazards Models
KW - Radiopharmaceuticals
KW - Tumor Burden
U2 - 10.1183/13993003.00099-2015
DO - 10.1183/13993003.00099-2015
M3 - Article
C2 - 26405289
SN - 0903-1936
VL - 46
SP - 1751
EP - 1761
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 6
ER -