PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study in children aged 10 to 17 years: Design, methods and baseline results

Elke Dorenbos, Mathijs Drummen, Jesse Rijks, Tanja Adam, Pauline Stouthart, J. Alfredo Martinez, Santiago Navas-Carretero, Gareth Stratton, Nils Swindell, Mikael Fogelholm, Anne Raben, Margriet Westerterp-Plantenga, Anita Vreugdenhil*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Insulin resistance (IR) in adolescence is associated with type 2 diabetes mellitus [T2DM]. The PREVIEW (Prevention of Diabetes Through Lifestyle Intervention and Population Studies in Europe and Around the World) study assessed the effectiveness of a high-protein, low-glycaemic-index diet and a moderate-protein, moderate-glycaemic-index diet to decrease IR in insulin-resistant children who were overweight or obese. Inclusion criteria were age 10 to 17 years, homeostatic model assessment of IR (HOMA-IR) >= 2.0 and overweight/obesity. In 126 children (mean +/- SD age 13.6 +/- 2.2 years, body mass index [BMI] z-score 3.04 +/- 0.66, HOMA-IR 3.48 +/- 2.28) anthropometrics, fat mass percentage (FM%), metabolic characteristics, physical activity, food intake and sleep were measured. Baseline characteristics did not differ between the groups. IR was higher in pubertal children with morbid obesity than in prepubertal children with morbid obesity (5.41 +/- 1.86 vs 3.23 +/- 1.86; P=.007) and prepubertal and pubertal children with overweight/obesity (vs 3.61 +/- 1.60, P=.004, and vs 3.40 +/- 1.50, P

Original languageEnglish
Pages (from-to)1096-1101
Number of pages6
JournalDiabetes Obesity & Metabolism
Volume20
Issue number5
DOIs
Publication statusPublished - May 2018

Keywords

  • dietary intervention
  • insulin resistance
  • randomized trial
  • type 2 diabetes
  • INSULIN-RESISTANCE
  • BODY-COMPOSITION
  • PUBERTAL CHANGES
  • ADOLESCENTS
  • OVERWEIGHT
  • INDEX
  • QUESTIONNAIRE
  • SENSITIVITY
  • DIETARY
  • PROTEIN

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