TY - JOUR
T1 - Prevention of asthma in genetically susceptible children: A multifaceted intervention trial focussed on feasibility in general practice
AU - Maas, Tanja
AU - Dompeling, Edward
AU - Muris, Jean W. M.
AU - Wesseling, Geertjan
AU - Knottnerus, J. Andre
AU - van Schayck, Onno C. P.
PY - 2011/12
Y1 - 2011/12
N2 - Background: Although the effectiveness of the multifaceted allergen-reducing interventions for the prevention of asthma in susceptible children was showed to be proven, the feasibility was not clear. Methods: The research question of the PREVention of asthma in susceptible children (PREVASC) trial was focused on the assessment of the effectiveness and feasibility of a multifaceted intervention on the prevention of allergic asthma in general practice. The effectiveness and feasibility of an intervention aimed at the simultaneous reduction in the environmental exposures to inhalant- and food allergens in susceptible children was investigated. A total of 476 children susceptible for developing asthma were initially included during pregnancy and were randomly divided over an intervention group of n = 222 children whose parents were offered a multifaceted environmental exposurereducing intervention. Controls (n = 221) received usual care. The main outcome was diagnosis of allergic asthma at age 6. Results: A significant reduction in inhalant allergen exposure levels of house dust mite [(Der p1), p = 0.043], cat [(Fel d1), p = 0.037], and dog [(Can f1), p = 0.012] was reached. Significantly more intervention group children started using cows milk and solids after the age of 6 months (p = 0.001). No statistical difference, however, was reached between groups on the duration of breast-feeding (p = 0.635) and the reduction in smoke exposure (p = 0829). At age 6, the intervention had no influence on the development of main outcome allergic asthma (OR = 1.010 (CI 0.5801.758). Conclusion: Other primary preventive asthma-reducing interventions were shown to be effective in reducing the occurrence of asthma for at least the first 78 yr of life. The multifaceted PREVASC allergic asthma primary preventive intervention was effective in reducing the exposure to inhalant and food allergens, but was not feasible for the parents. A lack of sufficient room for improvement focus on stimulating adherence seemed to be involved. It is suggested that a multifaceted environmental exposurereducing intervention may have to be adapted to the personal circumstances of patients at baseline.
AB - Background: Although the effectiveness of the multifaceted allergen-reducing interventions for the prevention of asthma in susceptible children was showed to be proven, the feasibility was not clear. Methods: The research question of the PREVention of asthma in susceptible children (PREVASC) trial was focused on the assessment of the effectiveness and feasibility of a multifaceted intervention on the prevention of allergic asthma in general practice. The effectiveness and feasibility of an intervention aimed at the simultaneous reduction in the environmental exposures to inhalant- and food allergens in susceptible children was investigated. A total of 476 children susceptible for developing asthma were initially included during pregnancy and were randomly divided over an intervention group of n = 222 children whose parents were offered a multifaceted environmental exposurereducing intervention. Controls (n = 221) received usual care. The main outcome was diagnosis of allergic asthma at age 6. Results: A significant reduction in inhalant allergen exposure levels of house dust mite [(Der p1), p = 0.043], cat [(Fel d1), p = 0.037], and dog [(Can f1), p = 0.012] was reached. Significantly more intervention group children started using cows milk and solids after the age of 6 months (p = 0.001). No statistical difference, however, was reached between groups on the duration of breast-feeding (p = 0.635) and the reduction in smoke exposure (p = 0829). At age 6, the intervention had no influence on the development of main outcome allergic asthma (OR = 1.010 (CI 0.5801.758). Conclusion: Other primary preventive asthma-reducing interventions were shown to be effective in reducing the occurrence of asthma for at least the first 78 yr of life. The multifaceted PREVASC allergic asthma primary preventive intervention was effective in reducing the exposure to inhalant and food allergens, but was not feasible for the parents. A lack of sufficient room for improvement focus on stimulating adherence seemed to be involved. It is suggested that a multifaceted environmental exposurereducing intervention may have to be adapted to the personal circumstances of patients at baseline.
KW - childhood asthma
KW - environment
KW - feasibility
KW - primary care
KW - randomized trials
U2 - 10.1111/j.1399-3038.2011.01192.x
DO - 10.1111/j.1399-3038.2011.01192.x
M3 - Article
C2 - 21749461
SN - 0905-6157
VL - 22
SP - 794
EP - 802
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 8
ER -