Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

Shumei Murakami; Rinus G. Verdonschot; Naoya Kakimoto; Iori Sumida; Masateru Fujiwara; Kazuhiko Ogawa; Souhei Furukawa

doi:10.1371/journal.pone.0154226

Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

Shumei Murakami, Rinus G. Verdonschot^*, Naoya Kakimoto, Iori Sumida, Masateru Fujiwara, Kazuhiko Ogawa, Souhei Furukawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purposetextlessbrtextgreater To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients.textlessbrtextgreater Methodstextlessbrtextgreater First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations.textlessbrtextgreater Resultstextlessbrtextgreater With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source.textlessbrtextgreater Conclusionstextlessbrtextgreater The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

Original language	English
Journal	PLOS ONE
Volume	11
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0154226
Publication status	Published - 2016
Externally published	Yes

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10.1371/journal.pone.0154226Licence: CC BY

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title = "Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer",

abstract = "Purposetextlessbrtextgreater To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients.textlessbrtextgreater Methodstextlessbrtextgreater First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations.textlessbrtextgreater Resultstextlessbrtextgreater With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source.textlessbrtextgreater Conclusionstextlessbrtextgreater The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.",

author = "Shumei Murakami and Verdonschot, {Rinus G.} and Naoya Kakimoto and Iori Sumida and Masateru Fujiwara and Kazuhiko Ogawa and Souhei Furukawa",

year = "2016",

doi = "10.1371/journal.pone.0154226",

language = "English",

volume = "11",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

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TY - JOUR

T1 - Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

AU - Murakami, Shumei

AU - Verdonschot, Rinus G.

AU - Kakimoto, Naoya

AU - Sumida, Iori

AU - Fujiwara, Masateru

AU - Ogawa, Kazuhiko

AU - Furukawa, Souhei

PY - 2016

Y1 - 2016

N2 - Purposetextlessbrtextgreater To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients.textlessbrtextgreater Methodstextlessbrtextgreater First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations.textlessbrtextgreater Resultstextlessbrtextgreater With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source.textlessbrtextgreater Conclusionstextlessbrtextgreater The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

AB - Purposetextlessbrtextgreater To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients.textlessbrtextgreater Methodstextlessbrtextgreater First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations.textlessbrtextgreater Resultstextlessbrtextgreater With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source.textlessbrtextgreater Conclusionstextlessbrtextgreater The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

U2 - 10.1371/journal.pone.0154226

DO - 10.1371/journal.pone.0154226

M3 - Article

SN - 1932-6203

VL - 11

JO - PLOS ONE

JF - PLOS ONE

IS - 4

ER -

Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

Abstract

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