TY - JOUR
T1 - Prevalence of- and risk factors for work disability in Dutch patients with inflammatory bowel disease
AU - Spekhorst, Lieke M.
AU - Oldenburg, Bas
AU - van Bodegraven, Ad A.
AU - de Jong, Dirk J.
AU - Imhann, Floris
AU - van der Meulen-de Jong, Andrea E.
AU - Pierik, Marieke J.
AU - van der Woude, Janneke C.
AU - Dijkstra, Gerard
AU - D'Haens, Geert
AU - Lowenberg, Mark
AU - Weersma, Rinse K.
AU - Festen, Eleonora A. M.
AU - Parelsnoer Inst Dutch Initiative C
PY - 2017/12/14
Y1 - 2017/12/14
N2 - AIMTo determine the prevalence of work disability in inflammatory bowel disease (IBD), and to assess risk factors associated with work disability.METHODSFor this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability (sick leave, partial and full disability) and long-term full work disability (> 80% work disability for > 2 years).RESULTSPrevalence of work disability was higher in Crohn's disease (CD) (29%) and ulcerative colitis (UC) (19%) patients compared to the general Dutch population (7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years, smoking, surgical interventions, and anti-TNF alpha use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level (OR = 1.62, 95% CI: 1.02-2.58), and in UC patients, disease complications (OR = 3.39, 95% CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSIONThe prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients.
AB - AIMTo determine the prevalence of work disability in inflammatory bowel disease (IBD), and to assess risk factors associated with work disability.METHODSFor this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability (sick leave, partial and full disability) and long-term full work disability (> 80% work disability for > 2 years).RESULTSPrevalence of work disability was higher in Crohn's disease (CD) (29%) and ulcerative colitis (UC) (19%) patients compared to the general Dutch population (7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years, smoking, surgical interventions, and anti-TNF alpha use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level (OR = 1.62, 95% CI: 1.02-2.58), and in UC patients, disease complications (OR = 3.39, 95% CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSIONThe prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients.
KW - Inflammatory bowel disease
KW - Crohn's disease
KW - Ulcerative colitis
KW - Work disability
KW - Health care costs
KW - QUALITY-OF-LIFE
KW - ULCERATIVE-COLITIS
KW - CROHNS-DISEASE
KW - SICK LEAVE
KW - UNEMPLOYMENT
KW - PROCTOCOLECTOMY
KW - PARTICIPATION
KW - POPULATION
KW - EMPLOYMENT
KW - THERAPY
U2 - 10.3748/wjg.v23.i46.8182
DO - 10.3748/wjg.v23.i46.8182
M3 - Article
C2 - 29290654
SN - 1007-9327
VL - 23
SP - 8182
EP - 8192
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 46
ER -