Prevalence, Factors Associated With, and Prognostic Effects of Preoperative Anemia on Short- and Long-Term Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation

Rutger-Jan Nuis, Jan-Malte Sinning, Josep Rodes-Cabau, Michael Gotzmann, Leen van Garsse, Joelle Kefer, Johan Bosmans, Gerald Yong, Antonio E. Dager, Ana Revilla-Orodea, Marina Urena, Georg Nickenig, Nikos Werner, Jos Maessen, Parla Astarci, Sergio Perez, Luis M. Benitez, Ignacio J. Amat-Santos, Javier Lopez, Eric DumontNicolas van Mieghem, Teun van Gelder, Ron T. van Domburg, Peter P. de Jaegere*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background There is scant information on the prevalence and factors associated with preoperative anemia in patients undergoing transcatheter aortic valve implantation (TAVI) and whether it is associated with mortality. We sought to determine the prevalence and factors associated with preoperative anemia in addition to the prognostic effects of the various levels of preoperative hemoglobin level on mortality in patients undergoing TAVI. Methods and Results Ten-center observational study encompassing 1696 patients with aortic stenosis who underwent TAVI was conducted. Anemia was defined by the World Health Organization criteria (hemoglobin 50% of patients undergoing TAVI. Various baseline factors were related to anemia, which in turn was associated with 1-year mortality. Patients with anemia received more transfusions but mostly for indications unrelated to overt bleeding, whereas transfusion was independently associated with both early and 1-year mortality. These findings indicate that optimization of baseline factors related to preoperative anemia, in addition to more strict criteria of the use of blood products, may improve outcome after TAVI.
Original languageEnglish
Pages (from-to)625-634
JournalCirculation-Cardiovascular Interventions
Issue number6
Publication statusPublished - Dec 2013


  • anemia
  • blood transfusion
  • hemoglobin

Cite this