Prevalence and prognostic relevance of cardiac involvement in ANCA-associated vasculitis: Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis

M. R. Hazebroek, M. J. Kemna, S. Schalla, S. Sanders-van Wijk, S. C. Gerretsen, R. Dennert, J. Merken, T. Kuznetsova, J. A. Staessen, H. P. Brunner-La Rocca, P. van Paassen, J. W. Cohen Tervaert, S. Heymans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

72 Citations (Web of Science)

Abstract

Background: To investigate the prevalence and prognostic relevance of cardiac involvement in an ANCA-associated vasculitis (AAV) population of eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA) patients. Methods: Prospective cohort study of fifty EGPA and forty-oneGPA patients in sustained remission without previous in-depth cardiac screening attending our clinical immunology outpatient department. Cardiac screening included clinical evaluation, ECG, 24-hour Holter registration, echocardiography and cardiac magnetic resonance imaging (CMR) with coronary angiography and endomyocardial biopsy upon indication. Fifty age-, sex- and cardiovascular risk factor-matched control subjects were randomly selected from a population study. Long-term outcome was assessed using all-cause and cardiovascular mortality. Results: A total of 91 AAV-patients (age 60 +/- 11, range 63-87 years) were compared to 50-matched control subjects (age 60 +/- 9 years, range 46-78 years). ECG and echocardiography demonstrated cardiac abnormalities in 62% EGPA and 46% GPA patients vs 20% controls (P <0.001 and P = 0.014, respectively). A total of 69 AAV-patients underwent additional CMR, slightly increasing the prevalence of cardiac involvement to 66% in EGPA and 61% in GPA patients. After a mean follow-up of 53 +/- 18 months, presence of cardiac involvement using ECG and echocardiography in AAV-patients showed increased all-cause and cardiovascular mortality (Log-rank P = 0.015 and Log-rank P = 0.021, respectively). Conclusion: Cardiac involvement in EGPA and GPA patients with sustained remission is high, even if symptoms are absent and ECG is normal. Moreover, cardiac involvement is a strong predictor of (cardiovascular) mortality. Therefore, risk stratification using cardiac imaging is recommended in all AAV-patients, irrespective of symptoms or ECG abnormalities.
Original languageEnglish
Pages (from-to)170-179
JournalInternational Journal of Cardiology
Volume199
DOIs
Publication statusPublished - 15 Nov 2015

Keywords

  • Granulomatosis with polyangiitis
  • Systemic vasculitis
  • Cardiovascular disease
  • Prognosis

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