Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Daan R. M. G. Ophelders; Ruth Gussenhoven; Luise Klein; Reint K. Jellema; Rob J. J. Westerlaken; Matthias C. Hutten; Jeroen Vermeulen; Guido Wassink; Alistair J. Gunn; Tim G. A. M. Wolfs

doi:10.3390/cells9081871

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Daan R. M. G. Ophelders, Ruth Gussenhoven, Luise Klein, Reint K. Jellema, Rob J. J. Westerlaken, Matthias C. Hutten, Jeroen Vermeulen, Guido Wassink, Alistair J. Gunn, Tim G. A. M. Wolfs^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

Original language	English
Article number	1871
Number of pages	42
Journal	Cells
Volume	9
Issue number	8
DOIs	https://doi.org/10.3390/cells9081871
Publication status	Published - Aug 2020

Keywords

preterm brain injury
hypoxia-ischemia
chorioamnionitis
timing
therapeutic hypothermia
stem cells
annexin A1
erythropoietin
biomarkers
MESENCHYMAL STEM-CELLS
WHITE-MATTER INJURY
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
RECOMBINANT-HUMAN-ERYTHROPOIETIN
MAGNETIC-RESONANCE-SPECTROSCOPY
JUNCTION PROTEIN EXPRESSION
ADULT PROGENITOR CELLS
BLOOD-BRAIN
BRONCHOPULMONARY DYSPLASIA
CEREBRAL HYPOTHERMIA

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title = "Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key",

abstract = "With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (",

keywords = "preterm brain injury, hypoxia-ischemia, chorioamnionitis, timing, therapeutic hypothermia, stem cells, annexin A1, erythropoietin, biomarkers, MESENCHYMAL STEM-CELLS, WHITE-MATTER INJURY, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, RECOMBINANT-HUMAN-ERYTHROPOIETIN, MAGNETIC-RESONANCE-SPECTROSCOPY, JUNCTION PROTEIN EXPRESSION, ADULT PROGENITOR CELLS, BLOOD-BRAIN, BRONCHOPULMONARY DYSPLASIA, CEREBRAL HYPOTHERMIA",

author = "Ophelders, \{Daan R. M. G.\} and Ruth Gussenhoven and Luise Klein and Jellema, \{Reint K.\} and Westerlaken, \{Rob J. J.\} and Hutten, \{Matthias C.\} and Jeroen Vermeulen and Guido Wassink and Gunn, \{Alistair J.\} and Wolfs, \{Tim G. A. M.\}",

year = "2020",

month = aug,

doi = "10.3390/cells9081871",

language = "English",

volume = "9",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

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T2 - Timing Is Key

AU - Ophelders, Daan R. M. G.

AU - Gussenhoven, Ruth

AU - Klein, Luise

AU - Jellema, Reint K.

AU - Westerlaken, Rob J. J.

AU - Hutten, Matthias C.

AU - Vermeulen, Jeroen

AU - Wassink, Guido

AU - Gunn, Alistair J.

AU - Wolfs, Tim G. A. M.

PY - 2020/8

Y1 - 2020/8

N2 - With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

AB - With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

KW - preterm brain injury

KW - hypoxia-ischemia

KW - chorioamnionitis

KW - timing

KW - therapeutic hypothermia

KW - stem cells

KW - annexin A1

KW - erythropoietin

KW - biomarkers

KW - MESENCHYMAL STEM-CELLS

KW - WHITE-MATTER INJURY

KW - HYPOXIC-ISCHEMIC ENCEPHALOPATHY

KW - RECOMBINANT-HUMAN-ERYTHROPOIETIN

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - JUNCTION PROTEIN EXPRESSION

KW - ADULT PROGENITOR CELLS

KW - BLOOD-BRAIN

KW - BRONCHOPULMONARY DYSPLASIA

KW - CEREBRAL HYPOTHERMIA

U2 - 10.3390/cells9081871

DO - 10.3390/cells9081871

M3 - (Systematic) Review article

C2 - 32785181

SN - 2073-4409

VL - 9

JO - Cells

JF - Cells

IS - 8

M1 - 1871

ER -

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Abstract

Keywords

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