Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Daan R. M. G. Ophelders; Ruth Gussenhoven; Luise Klein; Reint K. Jellema; Rob J. J. Westerlaken; Matthias C. Hutten; Jeroen Vermeulen; Guido Wassink; Alistair J. Gunn; Tim G. A. M. Wolfs

doi:10.3390/cells9081871

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Daan R. M. G. Ophelders
, Ruth Gussenhoven
, Luise Klein
, Reint K. Jellema
, Rob J. J. Westerlaken
, Matthias C. Hutten
, Jeroen Vermeulen
, Guido Wassink
, Alistair J. Gunn
, Tim G. A. M. Wolfs^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

Original language	English
Article number	1871
Number of pages	42
Journal	Cells
Volume	9
Issue number	8
DOIs	https://doi.org/10.3390/cells9081871
Publication status	Published - Aug 2020

Keywords

preterm brain injury
hypoxia-ischemia
chorioamnionitis
timing
therapeutic hypothermia
stem cells
annexin A1
erythropoietin
biomarkers
MESENCHYMAL STEM-CELLS
WHITE-MATTER INJURY
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
RECOMBINANT-HUMAN-ERYTHROPOIETIN
MAGNETIC-RESONANCE-SPECTROSCOPY
JUNCTION PROTEIN EXPRESSION
ADULT PROGENITOR CELLS
BLOOD-BRAIN
BRONCHOPULMONARY DYSPLASIA
CEREBRAL HYPOTHERMIA

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title = "Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key",

abstract = "With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (",

keywords = "preterm brain injury, hypoxia-ischemia, chorioamnionitis, timing, therapeutic hypothermia, stem cells, annexin A1, erythropoietin, biomarkers, MESENCHYMAL STEM-CELLS, WHITE-MATTER INJURY, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, RECOMBINANT-HUMAN-ERYTHROPOIETIN, MAGNETIC-RESONANCE-SPECTROSCOPY, JUNCTION PROTEIN EXPRESSION, ADULT PROGENITOR CELLS, BLOOD-BRAIN, BRONCHOPULMONARY DYSPLASIA, CEREBRAL HYPOTHERMIA",

author = "Ophelders, \{Daan R. M. G.\} and Ruth Gussenhoven and Luise Klein and Jellema, \{Reint K.\} and Westerlaken, \{Rob J. J.\} and Hutten, \{Matthias C.\} and Jeroen Vermeulen and Guido Wassink and Gunn, \{Alistair J.\} and Wolfs, \{Tim G. A. M.\}",

year = "2020",

month = aug,

doi = "10.3390/cells9081871",

language = "English",

volume = "9",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

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T2 - Timing Is Key

AU - Ophelders, Daan R. M. G.

AU - Gussenhoven, Ruth

AU - Klein, Luise

AU - Jellema, Reint K.

AU - Westerlaken, Rob J. J.

AU - Hutten, Matthias C.

AU - Vermeulen, Jeroen

AU - Wassink, Guido

AU - Gunn, Alistair J.

AU - Wolfs, Tim G. A. M.

PY - 2020/8

Y1 - 2020/8

N2 - With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

AB - With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

KW - preterm brain injury

KW - hypoxia-ischemia

KW - chorioamnionitis

KW - timing

KW - therapeutic hypothermia

KW - stem cells

KW - annexin A1

KW - erythropoietin

KW - biomarkers

KW - MESENCHYMAL STEM-CELLS

KW - WHITE-MATTER INJURY

KW - HYPOXIC-ISCHEMIC ENCEPHALOPATHY

KW - RECOMBINANT-HUMAN-ERYTHROPOIETIN

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - JUNCTION PROTEIN EXPRESSION

KW - ADULT PROGENITOR CELLS

KW - BLOOD-BRAIN

KW - BRONCHOPULMONARY DYSPLASIA

KW - CEREBRAL HYPOTHERMIA

U2 - 10.3390/cells9081871

DO - 10.3390/cells9081871

M3 - (Systematic) Review article

C2 - 32785181

SN - 2073-4409

VL - 9

JO - Cells

JF - Cells

IS - 8

M1 - 1871

ER -

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Abstract

Keywords

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