Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Daan R. M. G. Ophelders, Ruth Gussenhoven, Luise Klein, Reint K. Jellema, Rob J. J. Westerlaken, Matthias C. Hutten, Jeroen Vermeulen, Guido Wassink, Alistair J. Gunn, Tim G. A. M. Wolfs*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

21 Citations (Web of Science)

Abstract

With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic burden Preterm infants are predisposed to life-long neurological disorders due to the immaturity of the brain. The risks are inversely proportional to maturity at birth. In the majority of extremely preterm infants (

Original languageEnglish
Article number1871
Number of pages42
JournalCells
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • preterm brain injury
  • hypoxia-ischemia
  • chorioamnionitis
  • timing
  • therapeutic hypothermia
  • stem cells
  • annexin A1
  • erythropoietin
  • biomarkers
  • MESENCHYMAL STEM-CELLS
  • WHITE-MATTER INJURY
  • HYPOXIC-ISCHEMIC ENCEPHALOPATHY
  • RECOMBINANT-HUMAN-ERYTHROPOIETIN
  • MAGNETIC-RESONANCE-SPECTROSCOPY
  • JUNCTION PROTEIN EXPRESSION
  • ADULT PROGENITOR CELLS
  • BLOOD-BRAIN
  • BRONCHOPULMONARY DYSPLASIA
  • CEREBRAL HYPOTHERMIA

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