Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

A.M.M. Sonnenschein-van der Voort, L.R. Arends, J.C. de Jongste, I. Annesi-Maesano, S.H. Arshad, H. Barros, M. Basterrechea, H. Bisgaard, L. Chatzi, E. Corpeleijn, S. Correia, L.C. Craig, G. Devereux, C. Dogaru, M. Dostal, K. Duchen, M. Eggesbo, C.K. van der Ent, M.P. Fantini, F. ForastiereU. Frey, U. Gehring, D. Gori, A.C. van der Gugten, W. Hanke, A.J. Henderson, B. Heude, C. Iniguez, H.M. Inskip, T. Keil, C.C. Kelleher, M. Kogevinas, E. Kreiner-Moller, C.E. Kuehni, L.K. Küpers, K. Lancz, P.S. Larsen, S. Lau, J. Ludvigsson, M. Mommers, A.M.N. Andersen, L. Palkovicova, K.C. Pike, C. Pizzi, K. Polanska, D. Porta, L. Richiardi, G. Roberts, A. Schmidt, R.J. Sram, J. Sunyer, C. Thijs, M. Torrent, K. Viljoen, A.H. Wijga, M. Vrijheid, V.W.V. Jaddoe, L. Duijts

Research output: Contribution to journalArticleAcademicpeer-review

70 Citations (Scopus)

Abstract

Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age < 37 weeks) and low birth weight (< 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.
Original languageEnglish
Pages (from-to)1317-1329
JournalJournal of Allergy and Clinical Immunology
Volume133
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014

Cite this

Sonnenschein-van der Voort, A. M. M., Arends, L. R., de Jongste, J. C., Annesi-Maesano, I., Arshad, S. H., Barros, H., ... Duijts, L. (2014). Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. Journal of Allergy and Clinical Immunology, 133(5), 1317-1329. https://doi.org/10.1016/j.jaci.2013.12.1082
Sonnenschein-van der Voort, A.M.M. ; Arends, L.R. ; de Jongste, J.C. ; Annesi-Maesano, I. ; Arshad, S.H. ; Barros, H. ; Basterrechea, M. ; Bisgaard, H. ; Chatzi, L. ; Corpeleijn, E. ; Correia, S. ; Craig, L.C. ; Devereux, G. ; Dogaru, C. ; Dostal, M. ; Duchen, K. ; Eggesbo, M. ; van der Ent, C.K. ; Fantini, M.P. ; Forastiere, F. ; Frey, U. ; Gehring, U. ; Gori, D. ; van der Gugten, A.C. ; Hanke, W. ; Henderson, A.J. ; Heude, B. ; Iniguez, C. ; Inskip, H.M. ; Keil, T. ; Kelleher, C.C. ; Kogevinas, M. ; Kreiner-Moller, E. ; Kuehni, C.E. ; Küpers, L.K. ; Lancz, K. ; Larsen, P.S. ; Lau, S. ; Ludvigsson, J. ; Mommers, M. ; Andersen, A.M.N. ; Palkovicova, L. ; Pike, K.C. ; Pizzi, C. ; Polanska, K. ; Porta, D. ; Richiardi, L. ; Roberts, G. ; Schmidt, A. ; Sram, R.J. ; Sunyer, J. ; Thijs, C. ; Torrent, M. ; Viljoen, K. ; Wijga, A.H. ; Vrijheid, M. ; Jaddoe, V.W.V. ; Duijts, L. / Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. In: Journal of Allergy and Clinical Immunology. 2014 ; Vol. 133, No. 5. pp. 1317-1329.
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title = "Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children",
abstract = "Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age < 37 weeks) and low birth weight (< 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95{\%} CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95{\%} CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95{\%} CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95{\%} CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95{\%} CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.",
author = "{Sonnenschein-van der Voort}, A.M.M. and L.R. Arends and {de Jongste}, J.C. and I. Annesi-Maesano and S.H. Arshad and H. Barros and M. Basterrechea and H. Bisgaard and L. Chatzi and E. Corpeleijn and S. Correia and L.C. Craig and G. Devereux and C. Dogaru and M. Dostal and K. Duchen and M. Eggesbo and {van der Ent}, C.K. and M.P. Fantini and F. Forastiere and U. Frey and U. Gehring and D. Gori and {van der Gugten}, A.C. and W. Hanke and A.J. Henderson and B. Heude and C. Iniguez and H.M. Inskip and T. Keil and C.C. Kelleher and M. Kogevinas and E. Kreiner-Moller and C.E. Kuehni and L.K. K{\"u}pers and K. Lancz and P.S. Larsen and S. Lau and J. Ludvigsson and M. Mommers and A.M.N. Andersen and L. Palkovicova and K.C. Pike and C. Pizzi and K. Polanska and D. Porta and L. Richiardi and G. Roberts and A. Schmidt and R.J. Sram and J. Sunyer and C. Thijs and M. Torrent and K. Viljoen and A.H. Wijga and M. Vrijheid and V.W.V. Jaddoe and L. Duijts",
year = "2014",
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Sonnenschein-van der Voort, AMM, Arends, LR, de Jongste, JC, Annesi-Maesano, I, Arshad, SH, Barros, H, Basterrechea, M, Bisgaard, H, Chatzi, L, Corpeleijn, E, Correia, S, Craig, LC, Devereux, G, Dogaru, C, Dostal, M, Duchen, K, Eggesbo, M, van der Ent, CK, Fantini, MP, Forastiere, F, Frey, U, Gehring, U, Gori, D, van der Gugten, AC, Hanke, W, Henderson, AJ, Heude, B, Iniguez, C, Inskip, HM, Keil, T, Kelleher, CC, Kogevinas, M, Kreiner-Moller, E, Kuehni, CE, Küpers, LK, Lancz, K, Larsen, PS, Lau, S, Ludvigsson, J, Mommers, M, Andersen, AMN, Palkovicova, L, Pike, KC, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Roberts, G, Schmidt, A, Sram, RJ, Sunyer, J, Thijs, C, Torrent, M, Viljoen, K, Wijga, AH, Vrijheid, M, Jaddoe, VWV & Duijts, L 2014, 'Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children', Journal of Allergy and Clinical Immunology, vol. 133, no. 5, pp. 1317-1329. https://doi.org/10.1016/j.jaci.2013.12.1082

Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. / Sonnenschein-van der Voort, A.M.M.; Arends, L.R.; de Jongste, J.C.; Annesi-Maesano, I.; Arshad, S.H.; Barros, H.; Basterrechea, M.; Bisgaard, H.; Chatzi, L.; Corpeleijn, E.; Correia, S.; Craig, L.C.; Devereux, G.; Dogaru, C.; Dostal, M.; Duchen, K.; Eggesbo, M.; van der Ent, C.K.; Fantini, M.P.; Forastiere, F.; Frey, U.; Gehring, U.; Gori, D.; van der Gugten, A.C.; Hanke, W.; Henderson, A.J.; Heude, B.; Iniguez, C.; Inskip, H.M.; Keil, T.; Kelleher, C.C.; Kogevinas, M.; Kreiner-Moller, E.; Kuehni, C.E.; Küpers, L.K.; Lancz, K.; Larsen, P.S.; Lau, S.; Ludvigsson, J.; Mommers, M.; Andersen, A.M.N.; Palkovicova, L.; Pike, K.C.; Pizzi, C.; Polanska, K.; Porta, D.; Richiardi, L.; Roberts, G.; Schmidt, A.; Sram, R.J.; Sunyer, J.; Thijs, C.; Torrent, M.; Viljoen, K.; Wijga, A.H.; Vrijheid, M.; Jaddoe, V.W.V.; Duijts, L.

In: Journal of Allergy and Clinical Immunology, Vol. 133, No. 5, 01.01.2014, p. 1317-1329.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

AU - Sonnenschein-van der Voort, A.M.M.

AU - Arends, L.R.

AU - de Jongste, J.C.

AU - Annesi-Maesano, I.

AU - Arshad, S.H.

AU - Barros, H.

AU - Basterrechea, M.

AU - Bisgaard, H.

AU - Chatzi, L.

AU - Corpeleijn, E.

AU - Correia, S.

AU - Craig, L.C.

AU - Devereux, G.

AU - Dogaru, C.

AU - Dostal, M.

AU - Duchen, K.

AU - Eggesbo, M.

AU - van der Ent, C.K.

AU - Fantini, M.P.

AU - Forastiere, F.

AU - Frey, U.

AU - Gehring, U.

AU - Gori, D.

AU - van der Gugten, A.C.

AU - Hanke, W.

AU - Henderson, A.J.

AU - Heude, B.

AU - Iniguez, C.

AU - Inskip, H.M.

AU - Keil, T.

AU - Kelleher, C.C.

AU - Kogevinas, M.

AU - Kreiner-Moller, E.

AU - Kuehni, C.E.

AU - Küpers, L.K.

AU - Lancz, K.

AU - Larsen, P.S.

AU - Lau, S.

AU - Ludvigsson, J.

AU - Mommers, M.

AU - Andersen, A.M.N.

AU - Palkovicova, L.

AU - Pike, K.C.

AU - Pizzi, C.

AU - Polanska, K.

AU - Porta, D.

AU - Richiardi, L.

AU - Roberts, G.

AU - Schmidt, A.

AU - Sram, R.J.

AU - Sunyer, J.

AU - Thijs, C.

AU - Torrent, M.

AU - Viljoen, K.

AU - Wijga, A.H.

AU - Vrijheid, M.

AU - Jaddoe, V.W.V.

AU - Duijts, L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age < 37 weeks) and low birth weight (< 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

AB - Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age < 37 weeks) and low birth weight (< 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

U2 - 10.1016/j.jaci.2013.12.1082

DO - 10.1016/j.jaci.2013.12.1082

M3 - Article

VL - 133

SP - 1317

EP - 1329

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -

Sonnenschein-van der Voort AMM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H et al. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. Journal of Allergy and Clinical Immunology. 2014 Jan 1;133(5):1317-1329. https://doi.org/10.1016/j.jaci.2013.12.1082