TY - JOUR
T1 - Pressure and flow properties of cannulae for extracorporeal membrane oxygenation I
T2 - EuroELSO Congress 2019
AU - Broman, Lars Mikael
AU - Wittberg, Lisa Prahl
AU - Westlund, C. Jerker
AU - Gilbers, Martijn
AU - da Camara, Luisa Perry
AU - Swol, Justyna
AU - Taccone, Fabio S.
AU - Malfertheiner, Maximilian V.
AU - Di Nardo, Matteo
AU - Vercaemst, Leen
AU - Barrett, Nicholas A.
AU - Pappalardo, Federico
AU - Belohlavek, Jan
AU - Mueller, Thomas
AU - Belliato, Mirko
AU - Lorusso, Roberto
N1 - Conference code: 8
PY - 2019/4
Y1 - 2019/4
N2 - Adequate extracorporeal membrane oxygenation support in the adult requires cannulae permitting blood flows up to 6-8 L/minute. In accordance with Poiseuille's law, flow is proportional to the fourth power of cannula inner diameter and inversely proportional to its length. Poiseuille's law can be applied to obtain the pressure drop of an incompressible, Newtonian fluid (such as water) flowing in a cylindrical tube. However, as blood is a pseudoplastic non-Newtonian fluid, the validity of Poiseuille's law is questionable for prediction of cannula properties in clinical practice. Pressure-flow charts with non-Newtonian fluids, such as blood, are typically not provided by the manufacturers. A standardized laboratory test of return (arterial) cannulae for extracorporeal membrane oxygenation was performed. The aim was to determine pressure-flow data with human whole blood in addition to manufacturers' water tests to facilitate an appropriate choice of cannula for the desired flow range. In total, 14 cannulae from three manufacturers were tested. Data concerning design, characteristics, and performance were graphically presented for each tested cannula. Measured blood flows were in most cases 3-21% lower than those provided by manufacturers. This was most pronounced in the narrow cannulae (15-17 Fr) where the reduction ranged from 27% to 40% at low flows and 5-15% in the upper flow range. These differences were less apparent with increasing cannula diameter. There was a marked disparity between manufacturers. Based on the measured results, testing of cannulae including whole blood flows in a standardized bench test would be recommended.
AB - Adequate extracorporeal membrane oxygenation support in the adult requires cannulae permitting blood flows up to 6-8 L/minute. In accordance with Poiseuille's law, flow is proportional to the fourth power of cannula inner diameter and inversely proportional to its length. Poiseuille's law can be applied to obtain the pressure drop of an incompressible, Newtonian fluid (such as water) flowing in a cylindrical tube. However, as blood is a pseudoplastic non-Newtonian fluid, the validity of Poiseuille's law is questionable for prediction of cannula properties in clinical practice. Pressure-flow charts with non-Newtonian fluids, such as blood, are typically not provided by the manufacturers. A standardized laboratory test of return (arterial) cannulae for extracorporeal membrane oxygenation was performed. The aim was to determine pressure-flow data with human whole blood in addition to manufacturers' water tests to facilitate an appropriate choice of cannula for the desired flow range. In total, 14 cannulae from three manufacturers were tested. Data concerning design, characteristics, and performance were graphically presented for each tested cannula. Measured blood flows were in most cases 3-21% lower than those provided by manufacturers. This was most pronounced in the narrow cannulae (15-17 Fr) where the reduction ranged from 27% to 40% at low flows and 5-15% in the upper flow range. These differences were less apparent with increasing cannula diameter. There was a marked disparity between manufacturers. Based on the measured results, testing of cannulae including whole blood flows in a standardized bench test would be recommended.
KW - arterial
KW - return
KW - extracorporeal membrane oxygenation
KW - cannula
KW - pressure flow
KW - blood
KW - water
KW - extracorporeal life support
KW - NON-NEWTONIAN PROPERTIES
KW - NITRIC-OXIDE
KW - BLOOD
KW - TRANSFUSION
U2 - 10.1177/0267659119830521
DO - 10.1177/0267659119830521
M3 - Article
C2 - 30966910
SN - 0267-6591
VL - 34
SP - 58
EP - 64
JO - Perfusion
JF - Perfusion
Y2 - 10 April 2019 through 13 April 2019
ER -