Preservation techniques for donors after cardiac death kidneys

J. Wind, E.R. Hoogland, L.W.E. van Heurn

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE OF REVIEW: The purpose of the present review is to describe the techniques currently used to preserve kidneys from donors after cardiac death. RECENT FINDINGS: Automated chest compression devices may be used to improve organ perfusion between cardiac death and preservation measures. Normothermic extracorporeal membrane oxygenation reduces warm ischemic injury and has the ability to improve organ viability in donors after cardiac death. SUMMARY: Kidneys from donors after cardiac death expand the donor pool but are inevitably subjected to a period of warm ischemia. Reduction of warm ischemic injury to the organs improves transplant outcome. To reduce this injury in organs from donors after cardiac death, different preservation techniques are used. Automated chest compression devices improve organ perfusion between cardiac death and the start of organ preservation. In-situ preservation with double-balloon triple-lumen catheter is an easy technique to preserve organs in uncontrolled donors and is used in many centers to cool and flush the organs. In controlled donors, organs can also be flushed after laparotomy and direct cannulation of the aorta. Extracorporeal membrane oxygenation reduces warm ischemic injury and the use of normothermic perfusion seems promising. Optimal preservation is essential to improve the viability of kidneys from donors after cardiac death, to fully utilize this large donor pool.
Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalCurrent Opinion in Organ Transplantation
Volume16
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • donation after cardiac death
  • extracorporeal membrane oxygenation
  • in-situ preservation
  • kidney preservation
  • HEART-BEATING DONORS
  • EXTRACORPOREAL SUPPORT
  • RENAL-TRANSPLANTATION
  • ORGAN PROCUREMENT
  • DONATION
  • POOL
  • EXPERIENCE
  • IMPROVE
  • STREETS
  • ARREST

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