Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy

Yujing Wang, Abderazak Benzina, Daniel G. M. Molin, Nynke van den Akker, Mick Gagliardi, Leo H. Koole*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin, and sorafenib tosylate have been prepared by the emulsion solvent evaporation method with diameter between 200 and 400 mu m. Scanning electron microscopy showed that cisplatin microspheres had smooth surfaces, while sorafenib tosylate microspheres and cisplatin+sorafenib tosylate microspheres were porous at the surface and the pits of the latter were larger than those of the former. Notably, cisplatin+sorafenib tosylate microspheres had a fast drug release rate compared with microspheres containing one drug alone. In vitro cytotoxicity experiments and classical matrigel endothelial tube assay certificated the maintaining bioactivity of cisplatin and sorafenib tosylate released from the microspheres, respectively. This work provides a useful approach for the fabrication of drug-eluting beads used in transarterial chemoembolization.
Original languageEnglish
Pages (from-to)77-91
JournalJournal of Biomaterials Science-Polymer Edition
Volume26
Issue number2
DOIs
Publication statusPublished - 22 Jan 2015

Keywords

  • drug release
  • biodegradable
  • microspheres
  • sorafenib tosylate
  • TACE
  • tumor embolization

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