TY - JOUR
T1 - Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age - An exposome-based approach in 5 European cohorts
AU - Jedynak, P.
AU - Maitre, L.
AU - Guxens, M.
AU - Gutzkow, K.B.
AU - Julvez, J.
AU - Lopez-Vicente, M.
AU - Sunyer, J.
AU - Casas, M.
AU - Chatzi, L.
AU - Grazuleviciene, R.
AU - Kampouri, M.
AU - McEachan, R.
AU - Mon-Williams, M.
AU - Tamayo, I.
AU - Thomsen, C.
AU - Urquiza, J.
AU - Vafeiadi, M.
AU - Wright, J.
AU - Basagana, X.
AU - Vrijheid, M.
AU - Philippat, C.
N1 - Funding Information:
P. Jedynak was funded by the French National Research Agency in the framework of the Investissements d'Avenir program (ANR-15-IDEX-02). J. Julvez holds the Miguel Servet-II contract (CPII19/00015) awarded by the Instituto de Salud Carlos III (co-funded by the European Social Fund “Investing in your future”). The study has received funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308333 for the HELIX project. The present work relied on data from five out of six HELIX cohorts that received funding previously. INMA study data collection was supported by grants from the Instituto de Salud Carlos III, CIBERESP and the Generalitat de Catalunya-CIRIT (Spain). KANC study was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014-31V-66). The RHEA study was financially supported by European projects and the Greek Ministry of Health and Social Solidarity (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health and Child Health: 2012–2015). Core support for BiB study was provided by the Wellcome Trust (WT101597MA, UK). EDEN study was supported by grants from Foundation for Medical Research (FRM), Inserm, French Institute for Public Health Research (IReSP), Nestlé, French Ministry of Social Affairs and Health, French National Research Agency (ANR), Université Paris-Sud, French Institute for Public Health Surveillance (InVS), French Agency for Food, Environmental and Occupational Health & Safety (ANSES) and Mutuelle générale de l'Education nationale (MGEN).
Funding Information:
P. Jedynak was funded by the French National Research Agency in the framework of the Investissements d'Avenir program (ANR-15-IDEX-02). J. Julvez holds the Miguel Servet-II contract (CPII19/00015) awarded by the Instituto de Salud Carlos III (co-funded by the European Social Fund ?Investing in your future?). The study has received funding from the European Community's Seventh Framework Programme (FP7/2007?2013) under grant agreement no 308333 for the HELIX project. The present work relied on data from five out of six HELIX cohorts that received funding previously. INMA study data collection was supported by grants from the Instituto de Salud Carlos III, CIBERESP and the Generalitat de Catalunya-CIRIT (Spain). KANC study was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014-31V-66). The RHEA study was financially supported by European projects and the Greek Ministry of Health and Social Solidarity (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011?2014; ?Rhea Plus?: Primary Prevention Program of Environmental Risk Factors for Reproductive Health and Child Health: 2012?2015). Core support for BiB study was provided by the Wellcome Trust (WT101597MA, UK). EDEN study was supported by grants from Foundation for Medical Research (FRM), Inserm, French Institute for Public Health Research (IReSP), Nestl?, French Ministry of Social Affairs and Health, French National Research Agency (ANR), Universit? Paris-Sud, French Institute for Public Health Surveillance (InVS), French Agency for Food, Environmental and Occupational Health & Safety (ANSES) and Mutuelle g?n?rale de l'Education nationale (MGEN).
Publisher Copyright:
© 2020 The Authors
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures.Objective: This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour.Methods: We studied 703 mother-child pairs from five European cohorts recruited in 2003-2009 We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently.Results: LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01; 1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00; 1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRK: 0.90, 95%CI: 0.82; 0.98), perfluoroundecanoate (PFUnDA, IRR: 0.92, 95%CI: 0.84;0.99) and organochlorine compounds (OCs) were associated with lower risk of externalizing behaviour problems, however the associations with OCs were mainly seen among women with insufficient weight gain during pregnancy. Internalizing score worsen in association with exposure to diethyl thiophosphate (DETP, IRR: 1.11, 95%CI: 1.00;124) but the effect was driven by the smallest cohort. Internalizing score improved with increased concentration of perfluorooctane sulfonate (PFOS, IRR: 0.92, 95%CI: 0.85;1.00), however the association was driven by the two smallest cohorts with the lowest PFOS concentrations.Discussion: This study added evidence on deleterious effects of prenatal exposure to BPA and MnBP on child behaviour. Other associations should be interpreted cautiously since they were not consistent with previous studies or they have not been studied extensively. (C) 2020 The Authors. Published by Elsevier B.V.
AB - Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures.Objective: This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour.Methods: We studied 703 mother-child pairs from five European cohorts recruited in 2003-2009 We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently.Results: LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01; 1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00; 1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRK: 0.90, 95%CI: 0.82; 0.98), perfluoroundecanoate (PFUnDA, IRR: 0.92, 95%CI: 0.84;0.99) and organochlorine compounds (OCs) were associated with lower risk of externalizing behaviour problems, however the associations with OCs were mainly seen among women with insufficient weight gain during pregnancy. Internalizing score worsen in association with exposure to diethyl thiophosphate (DETP, IRR: 1.11, 95%CI: 1.00;124) but the effect was driven by the smallest cohort. Internalizing score improved with increased concentration of perfluorooctane sulfonate (PFOS, IRR: 0.92, 95%CI: 0.85;1.00), however the association was driven by the two smallest cohorts with the lowest PFOS concentrations.Discussion: This study added evidence on deleterious effects of prenatal exposure to BPA and MnBP on child behaviour. Other associations should be interpreted cautiously since they were not consistent with previous studies or they have not been studied extensively. (C) 2020 The Authors. Published by Elsevier B.V.
KW - birth cohort
KW - bisphenol-a exposure
KW - child behaviour
KW - copper
KW - developmental neurotoxicity
KW - hyperactivity
KW - imputation
KW - inner-city children
KW - internal exposome
KW - neuropsychological development
KW - organophosphate pesticide exposure
KW - persistent organic pollutants
KW - prenatal exposure
KW - strengths and difficulties questionnaire
KW - variable selection
KW - ORGANOPHOSPHATE PESTICIDE EXPOSURE
KW - NEUROPSYCHOLOGICAL DEVELOPMENT
KW - IMPUTATION
KW - COPPER
KW - Strengths and Difficulties Questionnaire
KW - BISPHENOL-A EXPOSURE
KW - Internal exposome
KW - Child behaviour
KW - Birth cohort
KW - DEVELOPMENTAL NEUROTOXICITY
KW - HYPERACTIVITY
KW - PERSISTENT ORGANIC POLLUTANTS
KW - VARIABLE SELECTION
KW - Prenatal exposure
KW - INNER-CITY CHILDREN
U2 - 10.1016/j.scitotenv.2020.144115
DO - 10.1016/j.scitotenv.2020.144115
M3 - Article
C2 - 33422710
SN - 0048-9697
VL - 763
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 144115
ER -