@article{9c46ddec4d8c4f77b07971bedf3f7285,
title = "Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts",
abstract = "Developing children are particularly vulnerable to the effects of exposure to per-and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is associated with poor metabolic health in children.We studied the association between prenatal and postnatal PFASs mixture exposure and cardiometabolic health in children, and the role of inflammatory proteins.In 1,101 mothers-child pairs from the Human Early Life Exposome project, we measured the concentrations of PFAS in blood collected in pregnancy and at 8 years (range = 6-12 years). We applied Bayesian Kernel Machine regression (BKMR) to estimate the associations between exposure to PFAS mixture and the cardiometabolic factors as age and sex-specific z-scores of waist circumference (WC), systolic and diastolic blood pressures (BP), and concentrations of triglycerides (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) cholesterol. We measured thirty six inflammatory biomarkers in child plasma and examined the underlying role of inflammatory status for the exposure-outcome association by integrating the three panels into a network.Exposure to the PFAS mixture was positively associated with HDL-C and systolic BP, and negatively associated with WC, LDL-C and TG. When we examined the independent effects of the individual chemicals in the mixture, prenatal PFHxS was negatively associated with HDL-C and prenatal PFNA was positively associated with WC and these were opposing directions from the overall mixture. Further, the network consisted of five distinct communities connected with positive and negative correlations. The selected inflammatory biomarkers were positively, while the postnatal PFAS were negatively related with the included cardiometabolic factors, and only prenatal PFOA was positively related with the pro-inflammatory cytokine IL-1beta and WC.Our study supports that prenatal, rather than postnatal, PFAS exposure might contribute to an unfavorable lipidemic profile and adiposity in childhood.",
keywords = "PFAS, Cardiometabolic risk, HDL, Inflammation, Adiposity, BKMR, PERFLUOROALKYL SUBSTANCES, PERFLUOROOCTANOIC ACID, METABOLIC SYNDROME, PERFLUORINATED CHEMICALS, NORWEGIAN MOTHER, YOUNG-CHILDREN, SERUM, CHILDHOOD, PROFILE, ASSOCIATION",
author = "E. Papadopoulou and N. Stratakis and X. Basagana and A.L. Brantsaeter and M. Casas and S. Fossati and R. Grazuleviciene and L.S. Haug and B. Heude and L. Maitre and R.R.C. McEachan and O. Robinson and T. Roumeliotaki and E. Sabido and E. Borras and J. Urquiza and M. Vafeiadi and Y.Q. Zhao and R. Slama and J. Wright and D.V. Conti and M. Vrijheid and L. Chatzi",
note = "Funding Information: Dr. Nikos Stratakis was supported by NIH/NIHES R21 ES029681 and P30 ES007048-23, and NIH/NIDDK P30 DK048522-24. Funding Information: We acknowledge the input of the entire HELIX consortium. We are grateful to all the participating families in the six countries who took part in this cohort study (BiB, EDEN,INMA,KANC,MoBa,andRhea cohorts) and those families who came in for a clinical examination of their children and who, in addition, donated blood and urine to this specific study. The authors are equally grateful to all the fieldworkers for their dedication and efficiency in this study. A full roster of the INMA and Rhea projects investigators can be found at: https://www.proyectoinma.org/proyecto-inma/investigadores/ and http://www.rhea.gr/en/about-rhea/the-rhea-team/. BiB is possible only because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, health professionals and researchers who have made BiB happen. Funding Information: The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I + D + i 2013–2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. Funding Information: This work was supported by the Norwegian Research Council under the MILJ{\O}FORSK-Milj{\o}forskning for en gr{\o}nn samfunnsomstilling call (project No. 268465-short name: {"}CATCHUP project{"}). Funding Information: For a full list of funding that supported the EDEN cohort, refer to: Heude B et al., Cohort Profile: The EDEN mother–child cohort on the prenatal and early postnatal determinants of child health and development. Int J Epidemiol. 2016 Apr;45(2):353–63. The Norwegian Mother, Father and Child Cohort Study (MoBa) is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011–2014; 'Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–2015). Funding Information: Dr. David Conti was supported by P01CA196569, R01CA140561, R01 ES016813, R01 ES029944, R01ES030691, R01ES030364. Funding Information: Dr. Leda Chatzi was supported by NIH/NIHES R01 ES029944, R01ES030691, R01ES030364, R21 ES029681, R21 ES028903, and P30 ES007048-23. Funding Information: ISGlobal affiliated researchers acknowledge support from the Spanish Ministry of Science, Innovation and Universities, “Centro de Excelencia Severo Ochoa 2013–2017”, SEV-2012–0208, and “Secretaria d{\textquoteright}Universitats i Recerca del Departament d{\textquoteright}Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595). Funding Information: The HELIX project is funded by the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308,333 – the HELIX project. The HELIX program is built on six existing cohorts that received previous funding, including the major ones listed below. The Born in Bradford (BiB) study presents independent research commissioned by the National Institute for Health Research Collaboration for Applied Health Research and Care (NIHR CLAHRC) and the Programme Grants for Applied Research funding scheme (RP-PG-0407–10044). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6–04-2014_31V-66). Funding Information: Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = dec,
day = "1",
doi = "10.1016/j.envint.2021.106853",
language = "English",
volume = "157",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Ltd",
}