Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project

Diana B. P. Clemente, Martine Vrijheid, Dries S. Martens, Mariona Bustamante, Leda Chatzi, Asta Danileviciute, Montserrat de Castro, Regina Grazideviciene, Kristine B. Gutzkow, Johanna Lepeule, Lea Maitre, Rosie R. C. McEachan, Oliver Robinson, Per E. Schwarze, Ibon Tamayo, Marina Vafeiadi, John Wright, Rimy Slama, Mark Nieuwenhuijsen, Tim S. Nawrot*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)

Abstract

BACKGROUND: Telomere length is a molecular marker of biological aging.

OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age.

METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n = 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameter

RESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2.5 exposures levels. Each standard deviation (SD) increase in prenatal NO(2 )was associated with a -1.5% (95% CI: -2.8, -0.2) change in LTL. Prenatal PM 2 . 5 was nonsignificantly associated with LTL (-0.7% per SD increase; 95% CI: -2.0, 0.6). For each SD increment in 1-y childhood NO2 and PM 2 . 5 exposure, LTL shortened by -1.6% (95% CI: -2.9, -0.4) and -1.4% (95% CI: -2.9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL.

CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward.

Original languageEnglish
Article number087001
Number of pages8
JournalEnvironmental Health Perspectives
Volume127
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • USE REGRESSION-MODELS
  • COHORT PROFILE
  • MULTIPLE IMPUTATION
  • PARTICULATE MATTER
  • CHAINED EQUATIONS
  • MORTALITY
  • HEALTH
  • CELL
  • PREGNANCY
  • RISK

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