TY - JOUR
T1 - Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children
T2 - The HELIX Project
AU - Clemente, Diana B. P.
AU - Vrijheid, Martine
AU - Martens, Dries S.
AU - Bustamante, Mariona
AU - Chatzi, Leda
AU - Danileviciute, Asta
AU - de Castro, Montserrat
AU - Grazideviciene, Regina
AU - Gutzkow, Kristine B.
AU - Lepeule, Johanna
AU - Maitre, Lea
AU - McEachan, Rosie R. C.
AU - Robinson, Oliver
AU - Schwarze, Per E.
AU - Tamayo, Ibon
AU - Vafeiadi, Marina
AU - Wright, John
AU - Slama, Rimy
AU - Nieuwenhuijsen, Mark
AU - Nawrot, Tim S.
N1 - Funding Information:
The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 308333 (the HELIX project) and from Instituto de Salud Carlos III (PI15/00118, including The European Regional Development Fund (FEDER)). T.S.N. was funded by the EU Program “Ideas” (ERC-2012-StG 310898). ISGlobal is a member of the Centres de Recerca de Catalunya (CERCA) Programme, Generalitat de Catalunya. We are grateful to all the participating families in the six countries who took part in this study.
Funding Information:
The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/ 2007–2013) under grant agreement no. 308333 (the HELIX project) and from Instituto de Salud Carlos III (PI15/00118, including The European Regional Development Fund (FEDER)). T.S.N. was funded by the EU Program “Ideas” (ERC-2012-StG 310898). ISGlobal is a member of the Centres de Recerca de Catalunya (CERCA) Programme, Generalitat de Catalunya. We are grateful to all the participating families in the six countries who took part in this study.
Publisher Copyright:
© 2019, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - BACKGROUND: Telomere length is a molecular marker of biological aging.OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age.METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n = 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameterRESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2.5 exposures levels. Each standard deviation (SD) increase in prenatal NO(2 )was associated with a -1.5% (95% CI: -2.8, -0.2) change in LTL. Prenatal PM 2 . 5 was nonsignificantly associated with LTL (-0.7% per SD increase; 95% CI: -2.0, 0.6). For each SD increment in 1-y childhood NO2 and PM 2 . 5 exposure, LTL shortened by -1.6% (95% CI: -2.9, -0.4) and -1.4% (95% CI: -2.9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL.CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward.
AB - BACKGROUND: Telomere length is a molecular marker of biological aging.OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age.METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n = 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameterRESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2.5 exposures levels. Each standard deviation (SD) increase in prenatal NO(2 )was associated with a -1.5% (95% CI: -2.8, -0.2) change in LTL. Prenatal PM 2 . 5 was nonsignificantly associated with LTL (-0.7% per SD increase; 95% CI: -2.0, 0.6). For each SD increment in 1-y childhood NO2 and PM 2 . 5 exposure, LTL shortened by -1.6% (95% CI: -2.9, -0.4) and -1.4% (95% CI: -2.9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL.CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward.
KW - CELL
KW - CHAINED EQUATIONS
KW - COHORT PROFILE
KW - HEALTH
KW - MORTALITY
KW - MULTIPLE IMPUTATION
KW - PARTICULATE MATTER
KW - PREGNANCY
KW - RISK
KW - USE REGRESSION-MODELS
U2 - 10.1289/EHP4148
DO - 10.1289/EHP4148
M3 - Article
SN - 0091-6765
VL - 127
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 8
M1 - 087001
ER -