Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry

Marco Pappaccogli; Aleksander Prejbisz; Simina Ciurica; Rosa Maria Bruno; Anna Aniszczuk-Hybiak; Irene Bracalente; Tine De Backer; Frederic Debieve; Philippe Delmotte; Silvia Di Monaco; Faical Jarraya; Daniel Gordin; Przemyslaw Kosinski; Abraham A. Kroon; Angela H. E. M. Maas; Denise Marcon; Pietro Minuz; Enrique Montagud-Marrahi; Agnes Pasquet; Esteban Poch; Franco Rabbia; George S. Stergiou; Ilkka Tikkanen; Laurent Toubiana; Wouter Vinck; Ewa Warchol-Celinska; Patricia Van der Niepen; Peter de Leeuw; Andrzej Januszewicz; Alexandre Persu

doi:10.1161/hypertensionaha.120.15349

Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry

Marco Pappaccogli, Aleksander Prejbisz, Simina Ciurica, Rosa Maria Bruno, Anna Aniszczuk-Hybiak, Irene Bracalente, Tine De Backer, Frederic Debieve, Philippe Delmotte, Silvia Di Monaco, Faical Jarraya, Daniel Gordin, Przemyslaw Kosinski, Abraham A. Kroon, Angela H. E. M. Maas, Denise Marcon, Pietro Minuz, Enrique Montagud-Marrahi, Agnes Pasquet, Esteban PochFranco Rabbia, George S. Stergiou, Ilkka Tikkanen, Laurent Toubiana, Wouter Vinck, Ewa Warchol-Celinska, Patricia Van der Niepen, Peter de Leeuw, Andrzej Januszewicz, Alexandre Persu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old;P

Original language	English
Pages (from-to)	545-553
Number of pages	9
Journal	Hypertension
Volume	76
Issue number	2
DOIs	https://doi.org/10.1161/hypertensionaha.120.15349
Publication status	Published - Aug 2020

Keywords

CARDIOLOGY
CLASSIFICATION
CORONARY-ARTERY DISSECTION
EUROPEAN-SOCIETY
HYPERTENSION
MANAGEMENT
PREECLAMPSIA
PREVALENCE
RISK-FACTORS
WOMEN
fibromuscular dysplasia
follow-up studies
hypertension
preeclampsia
pregnancy
pregnancy-induced
DIAGNOSIS
ANEURYSM
OUTCOMES

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10.1161/hypertensionaha.120.15349

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Cite this

Pappaccogli, M., Prejbisz, A., Ciurica, S., Bruno, R. M., Aniszczuk-Hybiak, A., Bracalente, I., De Backer, T., Debieve, F., Delmotte, P., Di Monaco, S., Jarraya, F., Gordin, D., Kosinski, P., Kroon, A. A., Maas, A. H. E. M., Marcon, D., Minuz, P., Montagud-Marrahi, E., Pasquet, A., ... Persu, A. (2020). Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry. Hypertension, 76(2), 545-553. https://doi.org/10.1161/hypertensionaha.120.15349

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title = "Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry",

abstract = "Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old;P",

keywords = "CARDIOLOGY, CLASSIFICATION, CORONARY-ARTERY DISSECTION, EUROPEAN-SOCIETY, HYPERTENSION, MANAGEMENT, PREECLAMPSIA, PREVALENCE, RISK-FACTORS, WOMEN, fibromuscular dysplasia, follow-up studies, hypertension, preeclampsia, pregnancy, pregnancy-induced, DIAGNOSIS, ANEURYSM, OUTCOMES",

author = "Marco Pappaccogli and Aleksander Prejbisz and Simina Ciurica and Bruno, {Rosa Maria} and Anna Aniszczuk-Hybiak and Irene Bracalente and {De Backer}, Tine and Frederic Debieve and Philippe Delmotte and {Di Monaco}, Silvia and Faical Jarraya and Daniel Gordin and Przemyslaw Kosinski and Kroon, {Abraham A.} and Maas, {Angela H. E. M.} and Denise Marcon and Pietro Minuz and Enrique Montagud-Marrahi and Agnes Pasquet and Esteban Poch and Franco Rabbia and Stergiou, {George S.} and Ilkka Tikkanen and Laurent Toubiana and Wouter Vinck and Ewa Warchol-Celinska and {Van der Niepen}, Patricia and {de Leeuw}, Peter and Andrzej Januszewicz and Alexandre Persu",

year = "2020",

month = aug,

doi = "10.1161/hypertensionaha.120.15349",

language = "English",

volume = "76",

pages = "545--553",

journal = "Hypertension",

issn = "0194-911X",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "2",

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Pappaccogli, M, Prejbisz, A, Ciurica, S, Bruno, RM, Aniszczuk-Hybiak, A, Bracalente, I, De Backer, T, Debieve, F, Delmotte, P, Di Monaco, S, Jarraya, F, Gordin, D, Kosinski, P, Kroon, AA, Maas, AHEM, Marcon, D, Minuz, P, Montagud-Marrahi, E, Pasquet, A, Poch, E, Rabbia, F, Stergiou, GS, Tikkanen, I, Toubiana, L, Vinck, W, Warchol-Celinska, E, Van der Niepen, P, de Leeuw, P, Januszewicz, A & Persu, A 2020, 'Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry', Hypertension, vol. 76, no. 2, pp. 545-553. https://doi.org/10.1161/hypertensionaha.120.15349

TY - JOUR

T1 - Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia

T2 - A Report From the European/International Fibromuscular Dysplasia Registry

AU - Pappaccogli, Marco

AU - Prejbisz, Aleksander

AU - Ciurica, Simina

AU - Bruno, Rosa Maria

AU - Aniszczuk-Hybiak, Anna

AU - Bracalente, Irene

AU - De Backer, Tine

AU - Debieve, Frederic

AU - Delmotte, Philippe

AU - Di Monaco, Silvia

AU - Jarraya, Faical

AU - Gordin, Daniel

AU - Kosinski, Przemyslaw

AU - Kroon, Abraham A.

AU - Maas, Angela H. E. M.

AU - Marcon, Denise

AU - Minuz, Pietro

AU - Montagud-Marrahi, Enrique

AU - Pasquet, Agnes

AU - Poch, Esteban

AU - Rabbia, Franco

AU - Stergiou, George S.

AU - Tikkanen, Ilkka

AU - Toubiana, Laurent

AU - Vinck, Wouter

AU - Warchol-Celinska, Ewa

AU - Van der Niepen, Patricia

AU - de Leeuw, Peter

AU - Januszewicz, Andrzej

AU - Persu, Alexandre

PY - 2020/8

Y1 - 2020/8

N2 - Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old;P

AB - Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old;P

KW - CARDIOLOGY

KW - CLASSIFICATION

KW - CORONARY-ARTERY DISSECTION

KW - EUROPEAN-SOCIETY

KW - HYPERTENSION

KW - MANAGEMENT

KW - PREECLAMPSIA

KW - PREVALENCE

KW - RISK-FACTORS

KW - WOMEN

KW - fibromuscular dysplasia

KW - follow-up studies

KW - hypertension

KW - preeclampsia

KW - pregnancy

KW - pregnancy-induced

KW - DIAGNOSIS

KW - ANEURYSM

KW - OUTCOMES

U2 - 10.1161/hypertensionaha.120.15349

DO - 10.1161/hypertensionaha.120.15349

M3 - Article

C2 - 32639884

SN - 0194-911X

VL - 76

SP - 545

EP - 553

JO - Hypertension

JF - Hypertension

IS - 2

ER -