Pregnancy in classic galactosemia despite undetectable anti-Mullerian hormone

C.S. Gubbels; S.M. Kuppens; J.A. Bakker; C.J. Konings; K.W. Wodzig; M.G. de Sain van der Velden; P.P. Menheere; M.E. Rubio Gozalbo

doi:10.1016/j.fertnstert.2008.12.031

Pregnancy in classic galactosemia despite undetectable anti-Mullerian hormone

C.S. Gubbels, S.M. Kuppens, J.A. Bakker, C.J. Konings, K.W. Wodzig, M.G. de Sain van der Velden, P.P. Menheere, M.E. Rubio Gozalbo^*

^*Corresponding author for this work

DA CDL Algemeen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To report a pregnancy in a patient with classic galactosemia despite signs of no ovarian reserve to draw attention to the limited predictive value of ovarian reserve tests in these patients. DESIGN: Case report. SETTING: Secondary and tertiary care center. PATIENT(S): A patient with classic galactosemia with premature ovarian failure and two previous pregnancies. INTERVENTION(S): Exogenous FSH ovarian reserve test and anti-Mullerian hormone (AMH) measurement. MAIN OUTCOME MEASURE(S): 17beta-Estradiol response, AMH level. RESULT(S): Pregnancy despite undetectable AMH (<0.1 microg/L) and no E(2) response (exogenous FSH ovarian reserve test). CONCLUSION(S): Fluctuating premature ovarian failure makes fertility counseling of patients with classic galactosemia difficult. Commonly used ovarian function and reserve tests seem to have no significance.

Original language	English
Pages (from-to)	1293.e13-16
Journal	Fertility and Sterility
Volume	91
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2008.12.031
Publication status	Published - 1 Jan 2009

Access to Document

10.1016/j.fertnstert.2008.12.031Licence: Free access - publisher

Cite this

@article{d3e3d236647d4e40a43cd5020528e679,

title = "Pregnancy in classic galactosemia despite undetectable anti-Mullerian hormone",

abstract = "OBJECTIVE: To report a pregnancy in a patient with classic galactosemia despite signs of no ovarian reserve to draw attention to the limited predictive value of ovarian reserve tests in these patients. DESIGN: Case report. SETTING: Secondary and tertiary care center. PATIENT(S): A patient with classic galactosemia with premature ovarian failure and two previous pregnancies. INTERVENTION(S): Exogenous FSH ovarian reserve test and anti-Mullerian hormone (AMH) measurement. MAIN OUTCOME MEASURE(S): 17beta-Estradiol response, AMH level. RESULT(S): Pregnancy despite undetectable AMH (<0.1 microg/L) and no E(2) response (exogenous FSH ovarian reserve test). CONCLUSION(S): Fluctuating premature ovarian failure makes fertility counseling of patients with classic galactosemia difficult. Commonly used ovarian function and reserve tests seem to have no significance.",

author = "C.S. Gubbels and S.M. Kuppens and J.A. Bakker and C.J. Konings and K.W. Wodzig and {de Sain van der Velden}, M.G. and P.P. Menheere and {Rubio Gozalbo}, M.E.",

year = "2009",

month = jan,

day = "1",

doi = "10.1016/j.fertnstert.2008.12.031",

language = "English",

volume = "91",

pages = "1293.e13--16",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Science",

number = "4",

}

TY - JOUR

T1 - Pregnancy in classic galactosemia despite undetectable anti-Mullerian hormone

AU - Gubbels, C.S.

AU - Kuppens, S.M.

AU - Bakker, J.A.

AU - Konings, C.J.

AU - Wodzig, K.W.

AU - de Sain van der Velden, M.G.

AU - Menheere, P.P.

AU - Rubio Gozalbo, M.E.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - OBJECTIVE: To report a pregnancy in a patient with classic galactosemia despite signs of no ovarian reserve to draw attention to the limited predictive value of ovarian reserve tests in these patients. DESIGN: Case report. SETTING: Secondary and tertiary care center. PATIENT(S): A patient with classic galactosemia with premature ovarian failure and two previous pregnancies. INTERVENTION(S): Exogenous FSH ovarian reserve test and anti-Mullerian hormone (AMH) measurement. MAIN OUTCOME MEASURE(S): 17beta-Estradiol response, AMH level. RESULT(S): Pregnancy despite undetectable AMH (<0.1 microg/L) and no E(2) response (exogenous FSH ovarian reserve test). CONCLUSION(S): Fluctuating premature ovarian failure makes fertility counseling of patients with classic galactosemia difficult. Commonly used ovarian function and reserve tests seem to have no significance.

AB - OBJECTIVE: To report a pregnancy in a patient with classic galactosemia despite signs of no ovarian reserve to draw attention to the limited predictive value of ovarian reserve tests in these patients. DESIGN: Case report. SETTING: Secondary and tertiary care center. PATIENT(S): A patient with classic galactosemia with premature ovarian failure and two previous pregnancies. INTERVENTION(S): Exogenous FSH ovarian reserve test and anti-Mullerian hormone (AMH) measurement. MAIN OUTCOME MEASURE(S): 17beta-Estradiol response, AMH level. RESULT(S): Pregnancy despite undetectable AMH (<0.1 microg/L) and no E(2) response (exogenous FSH ovarian reserve test). CONCLUSION(S): Fluctuating premature ovarian failure makes fertility counseling of patients with classic galactosemia difficult. Commonly used ovarian function and reserve tests seem to have no significance.

U2 - 10.1016/j.fertnstert.2008.12.031

DO - 10.1016/j.fertnstert.2008.12.031

M3 - Article

C2 - 19200962

SN - 0015-0282

VL - 91

SP - 1293.e13-16

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Pregnancy in classic galactosemia despite undetectable anti-Mullerian hormone

Abstract

Access to Document

Fingerprint

Cite this