TY - JOUR
T1 - Predictors of Growth of Vestibular Schwannoma After Gamma Knife Treatment
T2 - A Systematic Review
AU - Yang, Cheng
AU - Alvarado, Daniel
AU - Ravindran, Pawan Kishore
AU - Keizer, Max E.
AU - Hovinga, Koos
AU - Broen, Martinus P. G.
AU - Eekers, Danielle
AU - Compter, Inge
AU - Kunst, Henricus P. M.
AU - Temel, Yasin
PY - 2025/6/14
Y1 - 2025/6/14
N2 - Background: GKRS shows a high success rate in controlling growth of vestibular schwannoma, but a small number of tumors still grow after treatment. However, only a few studies have investigated the predictive factors of this growth. Objective: Here, we aim to explore the growth determinants of vestibular schwannoma after GKRS. Methods: This paper has analyzed literature published between 2000 and 2024 from PubMed, EMBASE, and Cochrane databases. Potential determinants, including age, gender, tumor volume, radiation dose, tumor location, and imaging characteristics, have been reviewed. Conclusions: We have found that initial tumor volume, pretreatment growth rate, and imaging ADC value potentially predict growth after GKRS. These findings provide a reference for further optimizing personalized treatment in vestibular schwannoma care.
AB - Background: GKRS shows a high success rate in controlling growth of vestibular schwannoma, but a small number of tumors still grow after treatment. However, only a few studies have investigated the predictive factors of this growth. Objective: Here, we aim to explore the growth determinants of vestibular schwannoma after GKRS. Methods: This paper has analyzed literature published between 2000 and 2024 from PubMed, EMBASE, and Cochrane databases. Potential determinants, including age, gender, tumor volume, radiation dose, tumor location, and imaging characteristics, have been reviewed. Conclusions: We have found that initial tumor volume, pretreatment growth rate, and imaging ADC value potentially predict growth after GKRS. These findings provide a reference for further optimizing personalized treatment in vestibular schwannoma care.
KW - systematic review
KW - vestibular schwannoma
KW - growth rate
KW - Gamma Knife
KW - skull base
KW - factors
KW - TUMOR-CONTROL
KW - RADIOSURGERY
KW - RADIOTHERAPY
KW - MANAGEMENT
KW - OUTCOMES
U2 - 10.3390/cancers17121993
DO - 10.3390/cancers17121993
M3 - (Systematic) Review article
SN - 2072-6694
VL - 17
JO - Cancers
JF - Cancers
IS - 12
M1 - 1993
ER -