Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO

M. E. Ketelaar*, K. D. van de Kant, F. N. Dijk, E. M. Klaassen, N. S. Grotenboer, M. C. Nawijn, E. Dompeling, G. H. Koppelman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Wheezing is common in childhood. However, current prediction models of pediatric asthma have only modest accuracy. Novel biomarkers and definition of subphenotypes may improve asthma prediction. Interleukin-1-receptor-like-1 (IL1RL1 or ST2) is a well-replicated asthma gene and associates with eosinophilia. We investigated whether serum sST2 predicts asthma and asthma with elevated exhaled NO (FeNO), compared to the commonly used Asthma Prediction Index (API). Using logistic regression modeling, we found that serum sST2 levels in 2-3 years-old wheezers do not predict doctors' diagnosed asthma at age 6 years. Instead, sST2 predicts a subphenotype of asthma characterized by increased levels of FeNO, a marker for eosinophilic airway inflammation. Herein, sST2 improved the predictive value of the API (AUC=0.70, 95% CI 0.56-0.84), but had also significant predictive value on its own (AUC=0.65, 95% CI 0.52-0.79). Our study indicates that sST2 in preschool wheezers has predictive value for the development of eosinophilic airway inflammation in asthmatic children at school age.

Original languageEnglish
Pages (from-to)1811-1815
Number of pages5
JournalAllergy
Volume72
Issue number11
DOIs
Publication statusPublished - Nov 2017

Keywords

  • childhood asthma
  • fraction of exhaled NO
  • prediction
  • preschool wheezers
  • serum sST2
  • EXHALED NITRIC-OXIDE
  • SOLUBLE ST2
  • ALLERGIC-ASTHMA
  • CHILDREN
  • IL-33
  • INFLAMMATION
  • BIOMARKERS
  • CHILDHOOD
  • IL1RL1
  • AGE

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