Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints.
Baars, M. A. E., van Boxtel, M. P. J., Dijkstra, J. B., Visser, P. J., van den Akker, M., Verhey, F. R. J., & Jolles, J. (2009). Predictive value of Mild Cognitive Impairment for dementia: the influence of case definition and age. Dementia and Geriatric Cognitive Disorders, 27, 173-181. https://doi.org/10.1159/000200465