Predictive value of Mild Cognitive Impairment for dementia: the influence of case definition and age.

M.A.E. Baars; M.P.J. van Boxtel; J.B. Dijkstra; P.J. Visser; M. van den Akker; F.R.J. Verhey; J. Jolles

doi:10.1159/000200465

Predictive value of Mild Cognitive Impairment for dementia: the influence of case definition and age.

M.A.E. Baars^*, M.P.J. van Boxtel, J.B. Dijkstra, P.J. Visser, M. van den Akker, F.R.J. Verhey, J. Jolles

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints.

Original language	English
Pages (from-to)	173-181
Journal	Dementia and Geriatric Cognitive Disorders
Volume	27
DOIs	https://doi.org/10.1159/000200465
Publication status	Published - 1 Jan 2009

Access to Document

10.1159/000200465

Cite this

@article{291e235fb168468abc0401fb87856aa9,

title = "Predictive value of Mild Cognitive Impairment for dementia: the influence of case definition and age.",

abstract = "Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints. ",

author = "M.A.E. Baars and {van Boxtel}, M.P.J. and J.B. Dijkstra and P.J. Visser and {van den Akker}, M. and F.R.J. Verhey and J. Jolles",

year = "2009",

month = jan,

day = "1",

doi = "10.1159/000200465",

language = "English",

volume = "27",

pages = "173--181",

journal = "Dementia and Geriatric Cognitive Disorders",

issn = "1420-8008",

publisher = "Karger",

}

TY - JOUR

T1 - Predictive value of Mild Cognitive Impairment for dementia: the influence of case definition and age.

AU - Baars, M.A.E.

AU - van Boxtel, M.P.J.

AU - Dijkstra, J.B.

AU - Visser, P.J.

AU - van den Akker, M.

AU - Verhey, F.R.J.

AU - Jolles, J.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints.

AB - Background/Aims: In population studies, different mild cognitive impairment (MCI) definitions have been used to predict dementia at a later stage. This study compared predictive values of different MCI definitions for dementia, and the effect of age on the predictive values was investigated. Methods: This study was conducted as part of an ongoing longitudinal study into the determinants of cognitive aging, the Maastricht Aging Study. Results: MCI best predicted dementia when multiple cognitive domains were considered and subjective complaints were not (sensitivity: 0.66, specificity: 0.78). Age had a strong influence on the sensitivity of MCI for dementia (age 60-70 years: sensitivity = 0.56; age 70-85 years: sensitivity = 0.70). Conclusion: The inclusion of multiple cognitive domains and participants aged 70 years and older leads to the best prediction of dementia, regardless of subjective complaints.

U2 - 10.1159/000200465

DO - 10.1159/000200465

M3 - Article

C2 - 19202336

SN - 1420-8008

VL - 27

SP - 173

EP - 181

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

ER -

Predictive value of Mild Cognitive Impairment for dementia: the influence of case definition and age.

Abstract

Access to Document

Fingerprint

Cite this