Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration

Matthias W. Lorenz; Lu Gao; Kathrin Ziegelbauer; Giuseppe Danilo Norata; Jean Philippe Empana; Irene Schmidtmann; Hung-Ju Lin; Stela McLachlan; Lena Bokemark; Kimmo Ronkainen; Mauro Amato; Ulf Schminke; Sathanur R. Srinivasan; Lars Lind; Shuhei Okazaki; Coen D. A. Stehouwer; Peter Willeit; Joseph F. Polak; Helmuth Steinmetz; Dirk Sander; Holger Poppert; Moise Desvarieux; M. Arfan Ikram; Stein Harald Johnsen; Daniel Staub; Cesare R. Sirtori; Bernhard Igiseder; Oscar Beloqui; Gunnar Engstrom; Alfonso Friera; Francesco Rozza; Wuxiang Xie; Grace Parraga; Liliana Grigore; Matthieu Plichart; Stefan Blankenberg; Ta-Chen Su; Caroline Schmidt; Tomi-Pekka Tuomainen; Fabrizio Veglia; Henry Volzke; Giel Nijpels; Johann Willeit; Ralph L. Sacco; Oscar H. Franco; Heiko Uthoff; Bo Hedblad; Carmen Suarez; Raffaele Izzo; Jing Liu; Dong Zhao; Thapat Wannarong; Alberico Catapano; Pierre Ducimetiere; Christine Espinola-Klein; Kuo-Liong Chien; Jackie F. Price; Goren Bergstrom; Jussi Kauhanen; Elena Tremoli; Marcus Dorr; Gerald Berenson; Kazuo Kitagawa; Jaqueline M. Dekker; Stefan Kiechl; Matthias Sitzer; Horst Bickel; Tatjana Rundek; Albert Hofman; Ellisiv B. Mathiesen; Samuela Castelnuovo; Manuel F. Landecho; Maria Rosvall; Rafael Gabriel; Nicola de Luca; Damiano Baldassarre; Maryam Kavousi; Eric de Groot; Michiel L. Bots; David N. Yanez; Simon G. Thompson; PROG-IMT Study Grp

doi:10.1371/journal.pone.0191172

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration

Matthias W. Lorenz^*, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R. Srinivasan, Lars Lind, Shuhei Okazaki, Coen D. A. Stehouwer, Peter Willeit, Joseph F. Polak, Helmuth Steinmetz, Dirk SanderHolger Poppert, Moise Desvarieux, M. Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R. Sirtori, Bernhard Igiseder, Oscar Beloqui, Gunnar Engstrom, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta-Chen Su, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Volzke, Giel Nijpels, Johann Willeit, Ralph L. Sacco, Oscar H. Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Jing Liu, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo-Liong Chien, Jackie F. Price, Goren Bergstrom, Jussi Kauhanen, Elena Tremoli, Marcus Dorr, Gerald Berenson, Kazuo Kitagawa, Jaqueline M. Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B. Mathiesen, Samuela Castelnuovo, Manuel F. Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L. Bots, David N. Yanez, Simon G. Thompson, PROG-IMT Study Grp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Original language	English
Article number	e0191172
Number of pages	19
Journal	PLOS ONE
Volume	13
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0191172
Publication status	Published - 12 Apr 2018

Keywords

ARTERY INTIMA
MYOCARDIAL-INFARCTION
ATHEROSCLEROSIS RISK
FOLLOW-UP
METABOLIC SYNDROME
HYPERTENSIVE MEN
VASCULAR RISK
PROGRESSION
POPULATION
DISEASE
Prognosis
Carotid Intima-Media Thickness
Humans
Intersectoral Collaboration
Middle Aged
Risk Factors
Male
Female
Aged
Cardiovascular Diseases/diagnosis

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Lorenz, M. W., Gao, L., Ziegelbauer, K., Norata, G. D., Empana, J. P., Schmidtmann, I., Lin, H-J., McLachlan, S., Bokemark, L., Ronkainen, K., Amato, M., Schminke, U., Srinivasan, S. R., Lind, L., Okazaki, S., Stehouwer, C. D. A., Willeit, P., Polak, J. F., Steinmetz, H., ... PROG-IMT Study Grp (2018). Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration . PLOS ONE, 13(4), Article e0191172. https://doi.org/10.1371/journal.pone.0191172

@article{17963f9135c549639685ff2444364293,

title = "Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration ",

abstract = "Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.",

keywords = "ARTERY INTIMA, MYOCARDIAL-INFARCTION, ATHEROSCLEROSIS RISK, FOLLOW-UP, METABOLIC SYNDROME, HYPERTENSIVE MEN, VASCULAR RISK, PROGRESSION, POPULATION, DISEASE, Prognosis, Carotid Intima-Media Thickness, Humans, Intersectoral Collaboration, Middle Aged, Risk Factors, Male, Female, Aged, Cardiovascular Diseases/diagnosis",

author = "Lorenz, {Matthias W.} and Lu Gao and Kathrin Ziegelbauer and Norata, {Giuseppe Danilo} and Empana, {Jean Philippe} and Irene Schmidtmann and Hung-Ju Lin and Stela McLachlan and Lena Bokemark and Kimmo Ronkainen and Mauro Amato and Ulf Schminke and Srinivasan, {Sathanur R.} and Lars Lind and Shuhei Okazaki and Stehouwer, {Coen D. A.} and Peter Willeit and Polak, {Joseph F.} and Helmuth Steinmetz and Dirk Sander and Holger Poppert and Moise Desvarieux and Ikram, {M. Arfan} and Johnsen, {Stein Harald} and Daniel Staub and Sirtori, {Cesare R.} and Bernhard Igiseder and Oscar Beloqui and Gunnar Engstrom and Alfonso Friera and Francesco Rozza and Wuxiang Xie and Grace Parraga and Liliana Grigore and Matthieu Plichart and Stefan Blankenberg and Ta-Chen Su and Caroline Schmidt and Tomi-Pekka Tuomainen and Fabrizio Veglia and Henry Volzke and Giel Nijpels and Johann Willeit and Sacco, {Ralph L.} and Franco, {Oscar H.} and Heiko Uthoff and Bo Hedblad and Carmen Suarez and Raffaele Izzo and Jing Liu and Dong Zhao and Thapat Wannarong and Alberico Catapano and Pierre Ducimetiere and Christine Espinola-Klein and Kuo-Liong Chien and Price, {Jackie F.} and Goren Bergstrom and Jussi Kauhanen and Elena Tremoli and Marcus Dorr and Gerald Berenson and Kazuo Kitagawa and Dekker, {Jaqueline M.} and Stefan Kiechl and Matthias Sitzer and Horst Bickel and Tatjana Rundek and Albert Hofman and Mathiesen, {Ellisiv B.} and Samuela Castelnuovo and Landecho, {Manuel F.} and Maria Rosvall and Rafael Gabriel and {de Luca}, Nicola and Damiano Baldassarre and Maryam Kavousi and {de Groot}, Eric and Bots, {Michiel L.} and Yanez, {David N.} and Thompson, {Simon G.} and {PROG-IMT Study Grp}",

year = "2018",

month = apr,

day = "12",

doi = "10.1371/journal.pone.0191172",

language = "English",

volume = "13",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

}

Lorenz, MW, Gao, L, Ziegelbauer, K, Norata, GD, Empana, JP, Schmidtmann, I, Lin, H-J, McLachlan, S, Bokemark, L, Ronkainen, K, Amato, M, Schminke, U, Srinivasan, SR, Lind, L, Okazaki, S, Stehouwer, CDA, Willeit, P, Polak, JF, Steinmetz, H, Sander, D, Poppert, H, Desvarieux, M, Ikram, MA, Johnsen, SH, Staub, D, Sirtori, CR, Igiseder, B, Beloqui, O, Engstrom, G, Friera, A, Rozza, F, Xie, W, Parraga, G, Grigore, L, Plichart, M, Blankenberg, S, Su, T-C, Schmidt, C, Tuomainen, T-P, Veglia, F, Volzke, H, Nijpels, G, Willeit, J, Sacco, RL, Franco, OH, Uthoff, H, Hedblad, B, Suarez, C, Izzo, R, Liu, J, Zhao, D, Wannarong, T, Catapano, A, Ducimetiere, P, Espinola-Klein, C, Chien, K-L, Price, JF, Bergstrom, G, Kauhanen, J, Tremoli, E, Dorr, M, Berenson, G, Kitagawa, K, Dekker, JM, Kiechl, S, Sitzer, M, Bickel, H, Rundek, T, Hofman, A, Mathiesen, EB, Castelnuovo, S, Landecho, MF, Rosvall, M, Gabriel, R, de Luca, N, Baldassarre, D, Kavousi, M, de Groot, E, Bots, ML, Yanez, DN, Thompson, SG & PROG-IMT Study Grp 2018, 'Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration ', PLOS ONE, vol. 13, no. 4, e0191172. https://doi.org/10.1371/journal.pone.0191172

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk: Results from the PROGIMT collaboration . / Lorenz, Matthias W.; Gao, Lu; Ziegelbauer, Kathrin et al.
In: PLOS ONE, Vol. 13, No. 4, e0191172, 12.04.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk

T2 - Results from the PROGIMT collaboration

AU - Lorenz, Matthias W.

AU - Gao, Lu

AU - Ziegelbauer, Kathrin

AU - Norata, Giuseppe Danilo

AU - Empana, Jean Philippe

AU - Schmidtmann, Irene

AU - Lin, Hung-Ju

AU - McLachlan, Stela

AU - Bokemark, Lena

AU - Ronkainen, Kimmo

AU - Amato, Mauro

AU - Schminke, Ulf

AU - Srinivasan, Sathanur R.

AU - Lind, Lars

AU - Okazaki, Shuhei

AU - Stehouwer, Coen D. A.

AU - Willeit, Peter

AU - Polak, Joseph F.

AU - Steinmetz, Helmuth

AU - Sander, Dirk

AU - Poppert, Holger

AU - Desvarieux, Moise

AU - Ikram, M. Arfan

AU - Johnsen, Stein Harald

AU - Staub, Daniel

AU - Sirtori, Cesare R.

AU - Igiseder, Bernhard

AU - Beloqui, Oscar

AU - Engstrom, Gunnar

AU - Friera, Alfonso

AU - Rozza, Francesco

AU - Xie, Wuxiang

AU - Parraga, Grace

AU - Grigore, Liliana

AU - Plichart, Matthieu

AU - Blankenberg, Stefan

AU - Su, Ta-Chen

AU - Schmidt, Caroline

AU - Tuomainen, Tomi-Pekka

AU - Veglia, Fabrizio

AU - Volzke, Henry

AU - Nijpels, Giel

AU - Willeit, Johann

AU - Sacco, Ralph L.

AU - Franco, Oscar H.

AU - Uthoff, Heiko

AU - Hedblad, Bo

AU - Suarez, Carmen

AU - Izzo, Raffaele

AU - Liu, Jing

AU - Zhao, Dong

AU - Wannarong, Thapat

AU - Catapano, Alberico

AU - Ducimetiere, Pierre

AU - Espinola-Klein, Christine

AU - Chien, Kuo-Liong

AU - Price, Jackie F.

AU - Bergstrom, Goren

AU - Kauhanen, Jussi

AU - Tremoli, Elena

AU - Dorr, Marcus

AU - Berenson, Gerald

AU - Kitagawa, Kazuo

AU - Dekker, Jaqueline M.

AU - Kiechl, Stefan

AU - Sitzer, Matthias

AU - Bickel, Horst

AU - Rundek, Tatjana

AU - Hofman, Albert

AU - Mathiesen, Ellisiv B.

AU - Castelnuovo, Samuela

AU - Landecho, Manuel F.

AU - Rosvall, Maria

AU - Gabriel, Rafael

AU - de Luca, Nicola

AU - Baldassarre, Damiano

AU - Kavousi, Maryam

AU - de Groot, Eric

AU - Bots, Michiel L.

AU - Yanez, David N.

AU - Thompson, Simon G.

AU - PROG-IMT Study Grp

PY - 2018/4/12

Y1 - 2018/4/12

N2 - Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

AB - Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

KW - ARTERY INTIMA

KW - MYOCARDIAL-INFARCTION

KW - ATHEROSCLEROSIS RISK

KW - FOLLOW-UP

KW - METABOLIC SYNDROME

KW - HYPERTENSIVE MEN

KW - VASCULAR RISK

KW - PROGRESSION

KW - POPULATION

KW - DISEASE

KW - Prognosis

KW - Carotid Intima-Media Thickness

KW - Humans

KW - Intersectoral Collaboration

KW - Middle Aged

KW - Risk Factors

KW - Male

KW - Female

KW - Aged

KW - Cardiovascular Diseases/diagnosis

U2 - 10.1371/journal.pone.0191172

DO - 10.1371/journal.pone.0191172

M3 - Article

C2 - 29649236

SN - 1932-6203

VL - 13

JO - PLOS ONE

JF - PLOS ONE

IS - 4

M1 - e0191172

ER -