TY - JOUR
T1 - Predictive Factors for Delivery within 7 Days after Successful 48-Hour Treatment of Threatened Preterm Labor.
AU - Roos, Carolien
AU - Schuit, Ewoud
AU - Scheepers, Hubertina C J
AU - Bloemenkamp, Kitty W M
AU - Bolte, Antoinette C
AU - Duvekot, Hans J J
AU - van Eyck, Jim
AU - Kok, Joke H
AU - Kwee, Anneke
AU - Merién, Ashley E R
AU - Opmeer, Brent C
AU - Oudijk, Martijn A
AU - van Pampus, Mariëlle G
AU - Papatsonis, Dimitri N M
AU - Porath, Martina M
AU - Sollie, Krystyna M
AU - Spaanderman, Marc E A
AU - Vijgen, Sylvia M C
AU - Willekes, Christine
AU - Lotgering, Fred K
AU - van der Post, Joris A M
AU - Mol, Ben Willem J
PY - 2015
Y1 - 2015
N2 - Objective The aim of this study was to assess which characteristics and results of vaginal examination are predictive for delivery within 7 days, in women with threatened preterm labor after initial treatment. Study Design A secondary analysis of a randomized controlled trial on maintenance nifedipine includes women who remained undelivered after threatened preterm labor for 48 hours. We developed one model for women with premature prelabor rupture of membranes (PPROM) and one without PPROM. The predictors were identified by backward selection. We assessed calibration and discrimination and used bootstrapping techniques to correct for potential overfitting. Results For women with PPROM (model 1), nulliparity, history of preterm birth, and vaginal bleeding were included in the multivariable analysis. For women without PPROM (model 2), maternal age, vaginal bleeding, cervical length, and fetal fibronectin (fFN) status were in the multivariable analysis. Discriminative capability was moderate to good (c-statistic 0.68; 95% confidence interval [CI] 0.60-0.77 for model 1 and 0.89; 95% CI, 0.84-0.93 for model 2). Conclusion PPROM and vaginal bleeding in the current pregnancy are relevant predictive factors in all women, as are maternal age, cervical length, and fFN in women without PPROM and nulliparity, history of preterm birth in women with PPROM.
AB - Objective The aim of this study was to assess which characteristics and results of vaginal examination are predictive for delivery within 7 days, in women with threatened preterm labor after initial treatment. Study Design A secondary analysis of a randomized controlled trial on maintenance nifedipine includes women who remained undelivered after threatened preterm labor for 48 hours. We developed one model for women with premature prelabor rupture of membranes (PPROM) and one without PPROM. The predictors were identified by backward selection. We assessed calibration and discrimination and used bootstrapping techniques to correct for potential overfitting. Results For women with PPROM (model 1), nulliparity, history of preterm birth, and vaginal bleeding were included in the multivariable analysis. For women without PPROM (model 2), maternal age, vaginal bleeding, cervical length, and fetal fibronectin (fFN) status were in the multivariable analysis. Discriminative capability was moderate to good (c-statistic 0.68; 95% confidence interval [CI] 0.60-0.77 for model 1 and 0.89; 95% CI, 0.84-0.93 for model 2). Conclusion PPROM and vaginal bleeding in the current pregnancy are relevant predictive factors in all women, as are maternal age, cervical length, and fFN in women without PPROM and nulliparity, history of preterm birth in women with PPROM.
U2 - 10.1055/s-0035-1552930
DO - 10.1055/s-0035-1552930
M3 - Article
C2 - 26495173
SN - 2157-6998
VL - 5
SP - e141-9
JO - American Journal of Perinatology Reports
JF - American Journal of Perinatology Reports
IS - 2
ER -